Composition and treatment with peptide combinations

Details Composition and treatment with peptide combinations Composition and treatment with peptide combinations

1991-05-10

1993-10-19

Wityshyn, Michael G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 12, 514 14, A61K 3702

Patent

active

052545377

ABSTRACT:
A composition comprising a magainin peptide or an analogue or derivative thereof, and at least one member selected from the group consisting of a PGLa peptide or analogue or derivative thereof, and an XPF peptide or analogue or derivative thereof. The composition is employed as a pharmaceutical.

REFERENCES:
M. Zasloff, "Magainins, a class of antimicrobial peptides from Xenopus skin: Isolation, characterization of two active forms, and partial cDNA sequence of a precursor," Proc. Natl. Acad. Sci., vol. 84, pp. 5449-5453 (Aug. 1987).
W. Hoffmann et al., "A novel peptide designated PYLa and its precursor as predicted from cloned mRNA of Xenopus laevis skin," EMBO J. 2:711-714, 1983.
Andreu et al., J. Biochem. 149:531-535, 1985.
Gibson et al., "Novel Peptide Fragments Originating from PGLa and the Caeruleinand Xenopsin Precursors from Xenopus laevis," J. Biol. Chem. 261:5341-5349, 1986.
Giovannini, et al., "Biosynthesis and degradation of peptides derived from Xenopus laevis prohormones," Biochem. J. 243:113-120, 1987.

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