Composition and treatment with biologically active peptides and

Details Composition and treatment with biologically active peptides and Composition and treatment with biologically active peptides and

1991-11-15

1993-05-04

Lee, Lester L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 12, 514 14, 530324, 530325, 530326, A61K 3702, C07K 710

Patent

active

052082202

ABSTRACT:
A composition comprising at least one biologically active amphiphilic peptide or protein, said peptide or protein being an ion channel-forming peptide or protein, and an antibiotic which inhibits DNA gyrase. The biologically active amphiphilic peptide and the antibiotic which inhibits DNA gyrase may be administered in amounts effective to inhibit growth of a target cell such as a bacterium.

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patent: 4962277 (1990-10-01), Cuervo et al.
Gibson, et al., "Novel Peptide Fragments Originating from PGLa and the Caerulein and Xenopsin Precursors from Xenopus laevis", Biol. Chem., vol. 261, No. 12 (Apr. 25, 1986).
Giovannini, et al., "Biosynthesis and Degradation of Peptides Derived from Xenopus laevis Prohormones,"Biochem J., vol. 243, pp. 113-120 (1987).
Viljanen, et al., "Susceptibility of Gram-Negative Bacteria to Polynyzin B Nonapeptide," Antimicrobial Agents and Chemotherapy, vol. 25, No. 6, pp. 701-705 (Jun. 1984).
Viljanen, et al., "Susceptibility of Gram-Negative Bacteria to the Synergistic Bactericidal Action of Serum and Polymyxin B Nonapeptide", Can. J. Microbiol., vol. 32, pp. 66-69 (1986).
Vaara, et al., Antimicrobial Agents and Chemotherapy, vol. 24, No. 1, pp. 107-113 (Jul. 1983).
Christensen, et al., Proc. Nat. Acad. Sci., vol. 85, pp. 5072-5076 (Jul. 1988).

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