Composition and treatment with biologically active peptides and

Details Composition and treatment with biologically active peptides and Composition and treatment with biologically active peptides and

1991-11-18

1993-06-22

Lee, Lester L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 12, 514 13, 514 21, 530324, 530325, 530326, 530350, 530842, A61K 3702, C07K 710

Patent

active

052216640

ABSTRACT:
A composition comprising a biologically active amphiphilic ion channel-forming peptide or ion channel forming protein and a toxic cation, such as a silver cation. Such compositions may be employed as pharmaceuticals, particularly for the treatment and prevention of eye infections.

REFERENCES:
patent: 4507230 (1985-03-01), Tam et al.
patent: 4962277 (1990-10-01), Cuervo et al.
Gibson, et al., "Novel Peptide Fragments Originating from PGLa and the Caerulein and Xenopsin Precursors" from Xenopus laevis, J. Biol. Chem., vol. 261, No. 12 (Apr. 25, 1986).
Giovannini, et al. "Biosynthesis and Degradation of Peptides Derived from Xenopus laevis Prohormones," Biochem J., vol. 243, pp. 113-120 (1987).
Christensen, et al., Proc. Nat. Acad. Sci., vol. 85, pp. 5072-5076 (Jul. 1988).

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