Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Cosmetic – antiperspirant – dentifrice
Patent
1997-06-19
2000-09-05
Page, Thurman K.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Cosmetic, antiperspirant, dentifrice
424 74, 4241951, A61K 600, A61K 700, A61K 706, A01N 6500
Patent
active
061139262
DESCRIPTION:
BRIEF SUMMARY
TECHNICAL SPHERE OF THE INVENTION
The present invention fits in the technical sphere of hormonal and/or antihormonal therapy, destinated to the maintenance of certain functions and structures that deteriorate with aging or due to other reasons and the treatment of several metabolic or degenerative illnesses and control of the growth, aspect, development and/or growth of certain structures, such as hair (excess or loss), corporal hair, prostate, skin and its problems (acne, rosacea . . . ), etc. which are influenced by the sex hormones levels (androgens and estrogens).
More exactly, the present invention refers to a new form of presentation for phytosterols with antiandrogenic action destinated to percutaneous topical application with cosmetic and/or pharmaceutical purposes.
STATE OF THE TECHNIC PREVIOUS TO THE INVENTION
The natural serols present and extracted from vegetal drugs, such as:
Serenoa sp. pl. Fam. Palmaccae. Spanish denomination: Sabal, palmeras de Florida, de Tejas y de Cuba. English den . . . Dwarfpalm. French Den.: Sabals, Serenoas. German Den.: Zwergpalmes, Sagepalmes. Italian Den.: Sabali.
Pygeum sp. pl. Fam. Rosaceae. Spanish Denomination: Ciruelos africanos. English Den.: African plums, French Den.: Pruniers d'Afrique. Italian Den.: Prune di Africa.
Epilobium sp. pl. Fam. Oenoteraccae. Spanish denomination: Epliobios. English Den.: Willow herbs, Rosebay. French Den.: Epliobes. German Den.: Waldroschens. Italian Den.: Epilobii.
Urtica dioica L. y Urtica sp. pl. Fam. Urticaceae. Spanish denomination: Ortigas mayores. English Den.: Nettle herbs, urtica y stinging nettles. German Den.: Brennesselkrauts, Haarnesselkrauts, Hanfnesselkrauts. French Den.: Herbes d'ortie. Italian Den.: Ortiche.
Hypoxis, sp. pl., specially the root of the Hypoxis rooperi and Hypoxis brasiliensis.
Cucurbita, sp. pl., Fam. Cucurbitaceae, specially the seeds of Curcurbita pepo y Cucurbita maxima (spanish, popular denomination: calabazas).
And other vegetal products such as bitter resins present in the strobila of Hop (Humulus lupulus L.; Fam Cannabaceao), also with antiandrogenic action are used in medicine orally for the treatment of prostate benign hypertrophy and other prostatic problems, femenin hirsutism and virilism.
Several of the vegetal extracts, rich in phytosterols, mentioned before, are being used orally as pharmaceutical specialities for the treatment of prostatic benign hypertrophy (Adriazola et al., 1992, Di-Silverio et al., 1992, Vahlensiek et al., 1993, Timmermans et al., 1990, Muhlbauer, 1991, Breu et al., 1992 y Sultan et al, 1984).
DESCRIPTION IN DETAIL OF THE INVENTION
The present invention, as exposed before, makes reference to a new cosmetic and pharmaceutical formulation based on extracts and galenic concentrates from vegetal drugs rich in sterols and/or others compounds (resins, etc.) with antiandrogenic action, for their percutaneous topical application.
The applicant has been able to verify, through his investigations, that the active principes of these vegetal drugs and specially the phytosterols and resin, etc. are absorbed well topically, mainly percutaneously.
Therefore, and accordingly to this finding, the inventors propose a novel cosmetic or pharmaceutical formule of presentation (topical) of these vegetal extracts, that we following enumerate:
Glycolic extracts of Dwarfpalms, of African plums, of Willow herbs, of Nettle herbs and of Hops.
Glyceric extracts of Dwarfpalms, of African plums, of Willow gerbs, of Nettle herbs and of Hops.
Hydroalcoholic extracts of Dwarfpalms, African plums, of Willow herbs, of Nettle herbs or Hops.
Lipidic-sterolic extracts of Dwarfpalms, of African plums, of Willow herbs, of Nettle herbs and of Hops.
Acetic extracts (vinegars) of Dwarfpalms, of African plums, of Willow herbs, of Nettle herbs and of Hops.
Chloroformic and ethereal extracts of Dwarfpalms, of African plums, of Willow herbs, of Nettle herbs and of Hops.
Dry extracts (and soft) of Dwarfpalms, of African plums, of Willow herbs, of Nettle herbs and of Hops.
All these extracts, individu
REFERENCES:
patent: 4569839 (1986-02-01), Grollier et al.
patent: 5641480 (1997-06-01), Vermeer
Gisbert Juan Bautista Peris
Soler Jose Cabo
Howard Sharon
Page Thurman K.
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