Composition and system for oral administration to animals

Details Composition and system for oral administration to animals Composition and system for oral administration to animals

1996-05-22

2000-01-04

Webman, Edward J.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Matrices

424501, A61K 910, A61K 916, A61K 4732

Patent

active

060107200

DESCRIPTION:

BRIEF SUMMARY
The present invention relates to a composition and to a system designed to allow the oral administration of chemicals or medicaments, such as vitamins, trace elements, amino acids, nutritional substances, vaccines and the like, to domestic or wild animals, such as mammals, fish, crustacea, and the like.
The present invention also relates to the method for producing the said systems and compositions.
Systems which allow the oral administration of medicaments to domestic animals, so as to avoid the parenteral route, which requires restraining the animal, are already known. Systems capable of treating animals raised extensively or wild animals, which are difficult or dangerous to restrain, are also known.
Such systems are the subject of Patent Applications or Patents (Patent EP 0 240 826, Patent EP 0 208 528 and Patent Application EP 0 421 863).
The bait described in Patent EP 0 240 826 is obtained by a first casting, at the bottom of a mould, of a support, comprising a lipid compound (having a melting point of between 20.degree. and 60.degree. C.), a compound designed to stabilize the shape of the bait and an attractive and palatable compound for the animals, introducing the active substance on the solidified support layer, under a second casting of the said support, so as to completely cover the said active substance.
This system has the disadvantage of exhibiting low mechanical strength and brittleness in the vicinity of the junction of the two castings and makes it unsuitable for large-scale distribution methods (aerial release, for example, for treating large numbers of wild animals, over large areas).
Patent EP 208 528 describes a bait for fish and crustacea consisting essentially of a water-insoluble polymer having a melting point of less than 110.degree. C. (polyamides or ethylene copolymers, EVA, in particular), of an attractive substance and of edible oil or of molasses (0 to 20%).
The baits according to this Patent EP 208 528 are obtained by extrusion at 90-110.degree. C. of a dry mixture of the polymer, the attractive substance and optionally the edible oil.
International Application WO 89/12393 describes pesticidal compositions comprising EVA, a bioactive agent, a source of proteins/sugars/lipids and optionally 0 to 20% edible oil, an attractive substance, a colorant, a preservative, a repelling agent and a biomarker.
The compositions according to this International Application PCT WO 89/12393 may be in the form of blocks or of tablets and are also prepared by extrusion of the abovementioned composition, either by melting the polymer (fused melt at a temperature <110.degree. C.) followed by the mixing of the latter with other ingredients, or by heating, up to the melting point of the polymer, a mixture of all the ingredients in a dry form.
Patent Application EP 421 863 describes systems comprising two parts: an envelope in tubular form, obtained by extrusion and comprising at least one attractive substances, at least one agglomerating substance (polysaccharides, starches or polymers such as EVA) and optionally a hydrophobic substance (oil) and inside the cavity of the envelope, a binding substance (mixture of fatty substances having a melting point which is not too high) containing an active ingredient, the binding substance taking the internal shape of the envelope. Such an envelope has a high mechanical and thermal strength which allows, in particular, distribution by aerial release.
The various systems obtained by extrusion exhibit, however, a number of disadvantages: which modifies their rate of release of these substances; in addition, such coated food particles are poorly assimilated, because of a poor assimilation of the polymers (resistance to enzymes in particular), is <110.degree. C. (EP 208 528, EP 421 863), components, which are then joined together: heterogeneous system or EP 0 240 826), withstand aerial release and/or extreme temperature conditions.
The aim of the present invention is, consequently, to provide a composition and a system which are more suitable for the requirem

REFERENCES:
patent: 5169645 (1992-12-01), Shukla et al.

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