Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1997-10-31
2000-12-26
Horlick, Kenneth R.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
435 71, 435 911, 435 912, 536 2433, C12Q 168, C07H 2104, C12P 1934
Patent
active
061657131
ABSTRACT:
Genomic sequences of human mismatch repair genes are described, as are methods of detecting mutations and/or polymorphisms in those genes. Also described are methods of diagnosing cancer susceptibility in a subject, and methods of identifying and classifying mismatch-repair-defective tumors. In particular, sequences and methods relating to human mutL homologs, hMLH1 and hPMS1 genes are provided.
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Baker Sean M.
Bollag Roni J.
Bronner C. Eric
Kolodner Richard D.
Liskay Robert M.
Dana-Farber Cancer Institute
Horlick Kenneth R.
Oregon Health & Sciences University
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