Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Reexamination Certificate
2004-06-03
2008-10-28
Qian, Celine X (Department: 1636)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
C536S023100, C435S320100
Reexamination Certificate
active
07442688
ABSTRACT:
Compositions and methods are disclosed for the therapeutic use of an atonal-associated nucleic acid or amino acid sequence. Also, an animal heterozygous for an atonal-associated gene inactivation is also disclosed having at least one atonal-associated nucleic acid sequence replaced by insertion of a heterologous nucleic acid sequence used to detect expression driven by an atonal-associated promoter sequence, wherein the inactivation of the atonal-associated nucleic acid sequence prevents expression of the atonal-associated gene.
REFERENCES:
patent: 5770580 (1998-06-01), Ledley et al.
patent: 5792751 (1998-08-01), Ledley et al.
patent: 5837681 (1998-11-01), Magal
patent: 5929041 (1999-07-01), Magal
patent: 0613945 (1994-09-01), None
patent: WO 95/19182 (1995-07-01), None
patent: WO 97/17983 (1997-05-01), None
patent: WO 98/00014 (1998-01-01), None
patent: WO 98/13048 (1998-04-01), None
patent: WO 98/19700 (1998-05-01), None
patent: WO 98/19700 (1998-05-01), None
patent: WO 99/06034 (1999-02-01), None
patent: WO 99/06064 (1999-02-01), None
patent: WO 99/42088 (1999-08-01), None
patent: WO 00/23084 (2000-04-01), None
patent: WO 00/27426 (2000-05-01), None
Schwarze SR et al., In vivoprotein transduction: delivery of a biologically active protein into the mouse, Science, Sep. 3, 1999, pp. 1569-1573, vol. 285, see entire document.
Verma IM et al.,Gene therapy-promises, problems&prospects, Nature, Sep. 18, 1997, pp. 239-242, pp. 239-242, vol. 389, see entire document.
Ledley FD,Pharmaceutical approach to somatic gene therapy, Pharmaceutical Research, Nov. 1996, pp. 1595-1614, vol. 13, No. 11, see entire document.
Chen, P., Johnson, J.E. et al., The role of Math 1 in inner ear development: Uncoupling the establishment of the sensory primordium from hair cell fate determination, Development, 2002, pp. 2495-2505, vol. 129.
Kanzaki, S., Kawamoto, K. et al., From Gene Identification to Gene Therapy, Audiol. Neurootol., 2002, pp. 161-164, vol. 7.
Kawamoto K., Oh, S.-H., et al., The Functional and Structural Outcome of Inner Ear Gene Transfer via the Vestibular and Cochlear Fluids in Mice, Molecular Therapy, Dec. 2001, vol. 4(6).
Zheng, J.L. and Gao, W.-Q., Overexpression of Math1 induces robust production of extra hair cells in postnatal rat inner ears, Nature Neuroscience, Jun. 2000, pp. 580-586, vol. 3(6).
Thibodeau, G.A., et al.,Sense of Hearing and Balance: The Ear, Unit 3, Communication, Control & Integration, Anatomy & Physiology, 4thEd., 1999, pp. 454-455, Mosby Inc., St. Louis, MO, USA.
Kawamoto, K., et al.,Math1 Gene Transfer Generated New Cochlear Hair Cells. . . , The Journal of Neuroscience, Jun. 1, 2003, pp. 4395-4400, 23(11), Society for Neuroscience.
Shou, J., et al.,Robust generation of new hair cells in the mature mammalian inner ear. . . , Molecular & Cellular Neuroscience, 2003, pp. 169-179, vol. 23, Elsevier Science (USA).
Dooling, R.J., et al.,Recovery of hearing and vocal behavior after hair-cell regeneration, Proc. Natl. Acad. Sci. USA, Psychology, Dec. 1997, pp. 14206-14210, vol. 94, The National Academy of Sciences.
Carey, J.P., et al.,Hair cell regeneration&recovery of the vestibuloocular reflex. . . , Journal of Neurophysiology, Nov. 1996, pp. 3301-3312+ cover, vol. 76, No. 5, The American Physiological Society.
Schwab, Markus, H., et al.; Neuronal Basic Helix-Loop-Helix Proteins (NEX, neuroD, NDRF): Spatiotemporal Expression and Targeted Disruption of the NEX Gene in Transgenic Mice, The Journal of Neuroscience (Feb. 15, 1998), OE(4), pp. 1408-1418.
Brown, Nadean, L., et al.; Math5 encodes a murine basic helix-loop-helix transcription factor expressed during early stages of retinal neurogensis, Development, (Nov. 9, 1998) vol. 125, pp. 4821-4833.
Ho, Alan, et al.; Synthetic Protein Transduction Domains: Enhanced Transduction Potential in Vitro and in Vivo; Cancer Research, vol. 61, pp. 474-477, Jan. 15, 2001.
Jero, Jussi, et al.; A surgical approach appropriate for targeted cochlear gene therapy in the mouse; Hearing Research, vol. 151, pp. 106-114, 2001.
Jero, Jussi, et al.; Cochlear Gene Delivery through an Intact Round Window membrane in Mouse; Human Gene Therapy; vol. 12, pp. 539-548, Mar. 20, 2001.
Lalwani, Anil K., et al.; Expression of Adeno-Associated Virus Integrated Transgene Within the Mammalian Vestibular Organs; Am J Otol 19:390-395, 1998.
Staecker, Hinrich, et al.; Brain-derived neurotropic factor gene therapy prevents spiral ganglion degeneration after hair cell loss; Otolaryngol Head Neck Surg 1998; 119:7-13.
Sherman, Michael P., et al.; HIV-1 Vpr Displays Natural Protein-Transducing Properties: Implications for Viral Pathogenesis; Virology 302, 95-105 (2002).
Ford, K.G., et al.; Protein transduction: an alternative to genetic intervention? Gene Therapy (2001) 8, 1-4.
Morris, May C., et al.; A peptide carrier for the delivery of biologically active proteins into mammalian cells; Nature Biotechnology, vol. 19, pp. 1173-1176, Dec. 2001.
Stöver, Timo, et al.; Cochlear gene transfer: round window versus cochleostomy inoculation; Hearing Research 136 (1999) 124-130.
Zheng JL et al.,Overexpression of Math1 induces robust productio of extra hair cells in postnatal rat inner ears; Nature Neuroscience, Jun. 2000, pp. 580-586, vol. 3, No. 6, Nature America Inc.
Eberl DF,Feeling the vibes: chorodotonal mechanisms in insect hearing, Current Opinion in Neurobiology, 1999, 9 pp.:in press.
Akazawa C et al.,A mammalian helix-loop-helix factor structurally related to the product drosophila proneural gene atonal is a positive transcriptional regulator expressed in the developing nervous system, The Journal of Biological Chemistry; Apr. 14, 1995, pp. 8730-8738, vol. 270, No. 15, The American Society of Biochemistry & Molecular Biology, Inc.
Sun Y et al.,Transcriptional regulation of atonal during development of the drosphila peripheral nervous system, Development 125, 1998, pp. 3731-3740, The Company of Biologists Limited, Great Britain.
Jarman AP et al.,Atonal is a proneural gene that directs chordotonal organ formation in the drosophila nervous system, Cell, Jul. 2, 1993, pp. 1307-1321, vol. 73, Cell Press.
Hassan BA et al.,Doing the math: is the mouse a good model for fly development? Genes & Development, 2000, pp. 1852-1865, vol. 14, Cold Spring Harbor Laboratory Press.
Hassan BA et al.,Atonal regulates neurite arborization but does not act as a proneural gene in the drosophila brain, Neuron, Mar. 2000, pp. 549-561, vol. 25, Cell Press.
Ben-Arie N et al.,Math1 is essential for genesis of cerebellar granule neurons, Nature, Nov. 13, 1997, pp. 169-172, vol. 390.
Bermingham NA et al.,Math1: an essential gene for the generation of inner ear hair cells, Science, Jun. 11, 1999, pp. 1837-1841, vol. 284, American Assoc. for the Advancement of Science.
Ben-Arie N et al.,Functional conservation of atonal and Math1 in the CNS&PNS, Development, 2000, pp. 1039-1048, vol. 127, The Company of Biologists Limited, Great Britain.
Ben-Arie N et al.,Evolutionary conservation of sequence&expression of the bHLH protein Atonal suggests a conserved role in neurogenesis, Human Molecular Genetics, 1996, pp. 1207-1216, vol. 5, Oxford Univ. Press.
Jarman AP et al.,Atonal is the proneural gene for Drosophila photoreceptors, Nature, Jun. 2, 1994, pp. 398-400, vol. 369.
Kim P et al.,XATH-1, a verterbrate homolog of Drosophila atonal, induces neuronal differentiation within ectodermal progenitors, Developmental Biology, Article D8978572, 1997, pp. 1-12, vol. 187, Academic Press.
Ben-Arie N et al.,Abnormal cerebellar development in mice lacking the murine homolog of the Drosophila proneural gene atonal, American J. Human Genetics, 1996, vol. 59, No. 4, Suppl. p. A46, Abstract #232, see abstract.
Sabate O et al.,Adenovirus for Neurodegenerative diseases:in vivostrategies& ex vivogene therapy using human neural progenitors, Clinical Neuroscience, 1996, pp. 317-321, vol. 3, especially p. 317, rt. col., and p. 318, left col.
Williams DP et al.,Structure/Function analysis of Interleukin-2-toxin(DAB486-IL-2),fragment B sequences required for th
Bellen Hugo
Ben-arie Nissim
Bermingham Nessan
Hassan Bassem
Zoghbi Huda Y.
Baylor College of Medicine
Fulbright & Jaworski LLP
Qian Celine X
LandOfFree
Composition and methods for the therapeutic use of an... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Composition and methods for the therapeutic use of an..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Composition and methods for the therapeutic use of an... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4000055