Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1998-03-03
2000-01-25
Davenport, Avis M.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
514 13, 514 14, 514 15, 514 16, 514 17, 530333, 530334, A61K 3800, A61K 3802, C07K 500, C07K 700
Patent
active
060178833
ABSTRACT:
The present invention relates to the identification, purification and characterization of novel factors which inhibit phagocyte activation, such as inhibiting polymorphonuclear neutrophil chemotaxis, degranulation and superoxide production. Disclosed are natural peptides purified from the bronchial environment and a variety synthetic peptides and analogues designed to have enhanced or longer-lasting phagocyte-inhibiting activity. The peptides and compositions of the present invention are contemplated for use in modulating inflammatory responses in a number of clinical settings, such as in the treatment of asthma, bronchitis, acute lung injury, rheumatoid arthritis, psoriasis, dermatitis and inflammatory bowel disease, and for use as anti-proliferative agents such as in the treatment of cancer.
REFERENCES:
Kalmokoff et al, Biochem Biophys Res Comm., vo. 1 167, Feb. 28, 1990, pp.154-160.
Cooper et al. Am J. Physiol., 260, pp. L501-L509, 1991.
Sibille et al., Am. J. Respir. Cell. Mol. Biol, vol. 1, 1989, pp. 407-416.
Davenport Avis M.
Research Corporation Technologies Inc.
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