Composition and methods for sterilizing dialyzers

Details Composition and methods for sterilizing dialyzers Composition and methods for sterilizing dialyzers

1995-04-03

1997-05-13

Warden, Robert J.

Chemical apparatus and process disinfecting, deodorizing, preser

Process disinfecting, preserving, deodorizing, or sterilizing

Using disinfecting or sterilizing substance

134 27, 422 44, 424665, A01N 2502, A01N 5908, A61L 218, B08B 308

Patent

active

056289596

ABSTRACT:
Compositions and methods are provided for sterilizing hemodialysis apparatus, particularly for reprocessing dialyzers in a manner that minimizes membrane perforations. The compositions contain a protic acid and a metal chlorite, and have a pH of at least about 2.3 and no greater than 4.2. Methods of this invention include contacting both the blood side and the dialysate side of a dialysis membrane with the composition, followed by first displacing the composition on the dialysate side with water or an aqueous alkali buffer having a pH in excess of about 6.0, such that the pH of the composition on the blood side of the dialysis membrane increases to at least about 5.0. The composition on the blood side is then displaced with saline. In a further embodiment, the composition has a pH ranging from 3.3 to 4.2, and the amount of chlorite ion in the form of chlorous acid ranges from 0.5% to 5.0% by weight of the total amount of chlorite ion in the composition. In this embodiment, the composition may be employed without associated membrane degradation by using existing hemodialysis set-up techniques, except that dialysate displacement on the dialysate side precedes saline displacement of blood side.

REFERENCES:
patent: 4104190 (1978-08-01), Hartshorn
patent: 4673506 (1987-06-01), Henne et al.
patent: 4690772 (1987-09-01), Tell et al.
patent: 5078967 (1992-01-01), Aixala
patent: 5178830 (1993-01-01), Aixala
patent: 5185161 (1993-02-01), Davidson et al.
patent: 5192459 (1993-03-01), Tell et al.

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