Composition and methods for modulating a kinase cascade

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

Reexamination Certificate

active

07851470

ABSTRACT:
The invention relates to compounds and methods for modulating one or more components of a kinase cascade.

REFERENCES:
patent: 3868380 (1975-02-01), Molteni et al.
patent: 6538960 (2003-03-01), Sabi et al.
patent: 6844367 (2005-01-01), Zhu et al.
patent: 7300931 (2007-11-01), Hangauer, Jr.
patent: 2004/0242572 (2004-12-01), Stenkamp et al.
patent: 2005/0059713 (2005-03-01), Mjalli et al.
patent: 2006/0160800 (2006-07-01), Hangauer, Jr.
patent: 2007/0015752 (2007-01-01), Hangauer, Jr.
patent: 2007/0197783 (2007-08-01), Hangauer, Jr.
patent: 0 463 638 (1992-01-01), None
patent: WO 96/12473 (1996-05-01), None
patent: WO 99/01127 (1999-01-01), None
patent: WO 01/85726 (2001-11-01), None
patent: WO 02/079197 (2002-10-01), None
patent: WO 03/059903 (2003-07-01), None
patent: WO 03/078404 (2003-09-01), None
patent: WO 03/087057 (2003-10-01), None
patent: WO 03/093297 (2003-11-01), None
patent: WO 2004/011427 (2004-02-01), None
patent: WO 2004/056774 (2004-07-01), None
patent: WO 2005/013914 (2005-02-01), None
patent: WO 2005/032493 (2005-04-01), None
patent: WO 2006/071960 (2006-07-01), None
patent: WO 2007/026920 (2007-03-01), None
Cain et al., “Potential Antitumor Agents. IX. Bisquaternary Salts”,J. Med. Chem., 11(5):963-966 (1968).
Davidson et al., “Discovery and characterization of a substrate selective p38α inhibitor”,Biochemistry, 43:11658-11671 (2004).
Duong et al., “Inhibition of osteoclast function by adenovirus expressing Antisense protein-tyrosine kinase 2”,J. Biol. Chem., 276(10):7484-7492 (2001).
Frame, M.C., “Src in cancer:deregulation and consequences for cell behaviour”,Biochem. Biophys. Acta, 1602:114-130 (2002).
Golub et al., “Molecular Classification of Cancer: Class Discovery and Class Prediction by Gene Expression Monitoring”,Science, 286:531-537 (1999).
Guo et al., “Tyrosine phosphorylation of the NR2B subunit of the NMDA receptor in the spinal cord during the development and maintenance of inflammatory hyperalgesia”,J. Neurosci., 22(14):6208-6217 (2002).
Hadjeri et al., “Antimitotic activity of 5-hydroxy-7-methoxy-2-phenyl-4-quinolones”.J. Med. Chem., 47:4964-4970 (2004).
Huff, J.R., “HIV Protease: A Novel Chemotherapeutic Target for AIDS”,J. Med. Chem., 34(8):2305-2314 (1991).
Lala et al., “Role of nitric oxide in tumor progression: Lessons from experimental tumors”,Cancer Metastasis Rev., 17(1):91-106 (1998).
Liechti et al., “Salicylanilides as inhibitors of the protein tyrosine kinase epidermal growth factor receptor”,Eur. J. Med. Chem., 39(1):11-26 (2004).
Million et al., “Inhibition of the EGF-stimulated cellular proliferation of ER 22 cells by hydroxybiphenyl derivatives”,J. Med. Chem., 38(23):4693-4703 (1995).
Miyazaki et al., “Src kinase activity is essential for osteoclast function”,J. Biol. Chem., 279(17):17660-17666 (2004).
Parang et al., “Recent advances in the discovery of Src kinase inhibitors”,Expert Opin. Ther. Patents, 15(9):1183-1207 (2005).
Paul et al., “Src deficiency or blockade of Src activity in mice provides cerebral protection following stroke”,Nat. Med., 7(2):222-227 (2001).
Rouhi, A.M., “The right stuff: From research and development to the clinic, getting drug crystals right is full of pitfalls”,Chem. Eng. News, pp. 32-35 (2003).
U.S. Pharmacopia #23, National Formulary #18, pp. 1843-1844 (1995).
Yu et al., “Src, a molecular switch governing gain control of synaptic transmission mediated by N-methyl-D-aspartate receptors”, Proc. Natl. Acad. Sci. USA, 96:7697-7704 (1999).
Zhang et al., “Design, synthesis, and SAR of anthranilamide-based factor Xa inhibitors incorporating substituted biphenyl P4 motifs”,Bioorg. Med. Chem. Lett., 14(4):983-987 (2004).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Composition and methods for modulating a kinase cascade does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Composition and methods for modulating a kinase cascade, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Composition and methods for modulating a kinase cascade will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-4190844

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.