Composition and method of use for liposome encapsulated compound

Details Composition and method of use for liposome encapsulated compound Composition and method of use for liposome encapsulated compound

1992-12-28

1994-07-12

Stoll, Robert L.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

Molecular bilayer structure

424450, A61K 4300, A61K 9133

Patent

active

053286782

ABSTRACT:
Liposomes with hyperosmotic concentration of compounds encapsulated therein are targeted to tumors for neutron capture therapy. The compounds have an element with a large neutron capture cross section and an isotope that emits alpha particles when bombarded with neutrons. A method employing such liposomes for neutron capture therapy is also described.

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Goldenburg, D. M. et al., Neutron-capture therapy of human cancer . . . , PNAS, 81:560-63 (1984).
Hatanaka et al., "A Revised Boron-Neutron Capture Therapy", Z. Neurol, 204, (1973), pp. 309-332.

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