Composition and method of preparing microparticles of water-inso

Details Composition and method of preparing microparticles of water-inso Composition and method of preparing microparticles of water-inso

1997-09-29

1999-07-13

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Particulate form

424461, 424464, 424468, 424450, A61K 914

Patent

active

059223553

ABSTRACT:
Submicron size particles of pharmaceutical or other water-insoluble or poorly water-insoluble substances are prepared using a combination of one or more surface modifiers/surfactants such as polaxomers, poloxamines, polyoxyethylene sorbitan fatty acid esters and the like together with natural or synthetic phospholipids. Particles so produced have a volume weighted mean particle size at least one-half smaller than obtainable using a phospholipid alone. Compositions so prepared are resistant to particle size growth on storage.

REFERENCES:
patent: 4411933 (1983-10-01), Samejima et al.
patent: 4963367 (1990-10-01), Ecanow
patent: 5091187 (1992-02-01), Haynes
patent: 5326552 (1994-07-01), Na et al.
patent: 5364633 (1994-11-01), Hill et al.
patent: 5389377 (1995-02-01), Chagnon et al.
patent: 5447710 (1995-09-01), Na et al.

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