Composition and method of MRI using both a positive and a negati

Details Composition and method of MRI using both a positive and a negati Composition and method of MRI using both a positive and a negati

1996-02-16

1999-01-26

Dees, Jose G.

Drug, bio-affecting and body treating compositions

In vivo diagnosis or in vivo testing

Magnetic imaging agent

424 93, A61B 5055

Patent

active

058635190

ABSTRACT:
There is provided a contrast medium composition comprising: (a) a first contrast agent comprising a physiologically tolerable manganese compound together with an uptake promoter, having a manganese concentration of at least 0.3 mM or being in a dosage unit form containing at least 300 .mu.mol manganese, wherein the uptake promoter comprises a physiologically tolerable reducing compound containing an .alpha.-hydroxy ketone group or a physiologically tolerable acid containing .alpha.- and/or .beta.- hydroxy or amino groups, or a salt thereof, and/or vitamin D; together with (b) a second contrast agent.
Such compositions are particularly suitable for imaging of the liver.

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