Composition and method for treatment of hepatic encephalopathy

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

Reexamination Certificate

active

10748185

ABSTRACT:
The inventions provide an improved treatment for hepatic encephalopathy characterized by hyperammonemia and/or constipation, comprising the oral administration of polyethylene glycol (PEG) in amounts sufficient to reduce plasma levels of ammonia and/or to alleviate constipation. Preferably, the PEG is administered in combination with lactulose, which provides a palatable composition for the treatment of HE with excellent therapeutic benefits and reduced side effects as compared to lactulose alone.

REFERENCES:
patent: 3505309 (1970-04-01), Carubelli
patent: 3716408 (1973-02-01), Nagasawa et al.
patent: 4057655 (1977-11-01), Okada et al.
patent: 4100293 (1978-07-01), Walser
patent: 4147773 (1979-04-01), Ogasa
patent: 4996236 (1991-02-01), Nakamura et al.
patent: 5326405 (1994-07-01), Pluim et al.
patent: 5415695 (1995-05-01), Weterings et al.
patent: 5571783 (1996-11-01), Montagne et al.
patent: 5688521 (1997-11-01), Bolder et al.
patent: 6444198 (2002-09-01), Daggy et al.
patent: 6488969 (2002-12-01), Tsutsumi et al.
patent: 6645481 (2003-11-01), Cleveland et al.
patent: 2005/0152989 (2005-07-01), Pelham et al.
patent: 1230918 (2002-08-01), None
Mosby's (Mosby's GenRx: The complete reference for generic and brand drugs, Eighth Edition, 1998, Mosby—Year Book Inc., Publishers, St. Louis, p. II-1169 & II-1770).
Roblin, et al. (“Use of polyethylene glycol 4000 in hepatic encephalopathy related to digestive hemorrages,” Gastroenterol Clin Biol 1994 18(12): 1146)—Full article from French.
“Duphalac Dry” product information brochure, www.intekom.com, publication date May 27, 1994.
Bond et al., Journal of Laboratory and Clinical Medicine, 1975, 85(4), pp. 546-555.
“Ammonia”, www.labtestonline.org, 2004.
“Encephalopathy, Hepatic”, www.emedicine, 2006.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Composition and method for treatment of hepatic encephalopathy does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Composition and method for treatment of hepatic encephalopathy, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Composition and method for treatment of hepatic encephalopathy will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3861817

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.