Composition and method for treatment of CMV retinites

Details Composition and method for treatment of CMV retinites Composition and method for treatment of CMV retinites

1994-04-26

1997-01-21

Leguyader, John L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

435 6, 435 911, 536 231, 536 245, A61K 4800, C12Q 168, C07H 2104

Patent

active

055959784

ABSTRACT:
This invention concerns compositions and methods for the treatment of CMV infections. A composition including an antisense oligonucleotide targeted to the IE2 gene of CMV and a pharmaceutically acceptable carrier were used stop progression in CMV retinitis.

REFERENCES:
patent: 5034506 (1994-07-01), Summerton et al.
Azad et al. Anti Agents and Chemo Therp. Sep. 1993, vol. 37, pp. 1945-1954.
Stenberg et al. J. Vir. Dec. 1985, vol. 56 pp. 665-675.
Pam et al. Clin. Pharm. Aug 1990, vol. 9, pp. 613-631.
Uhlmann et al. Chem. Res. Jun. 1990, vol. 90, 544-579.
Stein et al. Science 261:1004 (1993).
Gennaro, Alfonso, Ed., Remington's Pharmaceutical Sciences, 18th Edition 1990. Mack Publishing Co., Easton, Pa.
P. E. Nielsen, M. Egholm, R. H. Berg, O. Buchardt, "Sequence-Selective Recognition of DNA by Strand Displacement with a Thymine-Substituted Polyamide", Science 1991, 254, 1497.
Flores-Aquiler et al. 7th Internal. Conf. on Antivir. Res. 23 (Suppl. 1) 1994 (89).

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