Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Patent
1997-04-09
2000-11-28
Schwartzman, Robert A.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
435 6, 435 911, 435375, 536 231, 536 2431, 536 2433, 536 245, A61K 4800, C12Q 168, C07H 2104
Patent
active
061535958
ABSTRACT:
This invention concerns compositions and methods for the treatment of CMV infections. Antisense oligonucleotides are provided which are effective antiviral agents. In preferred embodiments, the oligonucleotides contain at least one 2'-methoxyethoxy modification and may be chimeric oligonucleotides.
REFERENCES:
patent: 5034506 (1991-07-01), Summerton et al.
patent: 5138045 (1992-08-01), Cook et al.
patent: 5218105 (1993-06-01), Cook et al.
patent: 5442049 (1995-08-01), Anderson et al.
patent: 5459255 (1995-10-01), Cook et al.
patent: 5591720 (1997-01-01), Anderson et al.
patent: 5595978 (1997-01-01), Draper et al.
patent: 5767102 (1998-06-01), Draper et al.
patent: 5789573 (1998-08-01), Baker et al.
patent: 5801154 (1998-09-01), Berlaechini et al.
Anderson et al., "Inhibition of Human Ctyomegalovirus Immediate-Early Gene Expression by an Antisense Oligonucleotide Complementary to Immediate-Early RNA", Antimicrob. Agents and Chemother. 1996, 40, 2004-2011.
Brigstock et al., "Species-Specific High Molecular Weight Forms of Basic Fibrobalst Growth Factor", Growth Factors 1990, 4, 45-52.
Cohen, J., "New Hope Against Blindness", Science 1995, 268, 368-9.
Crooke et al., "Pharmacokinetic Properties of Several Novel Oligonucledotide Analogs in mice", J. Pharmacol. Exp. Ther. 1996, 277, 923-937.
De Mesmaeker et al., "Antisense Oligonucleotides", Acc. Chem. Res. 1995, 28, 366-374.
DeVirgilio et al., "Cloning and Disruption of a Gene Required for Growth on Acetate but not on Ethanol: the Acetyl-Coenzyme A Synthetase Gene of Saccharomyces cerevisiae", Yeast 1992, 8, 1043-1051.
French et al., "Expression of Two Related Nonstructural Proteins of Bluetongue Virust (BTV) Type 10 in Insect Cells by a Recombinant Baculovirus: Production of Polyclonal Ascitic Fluid and Characterization of the Gene Product in BTV-Infected BHK Cells" J. Virol. 1989, 63, 3270-3278.
Gao et al., "Cloning and Characterization of a Mouse Gene with Homology to the Human von Hippel-Lindau Disease Tumor Suppressor Gene: Implications for the Potential Organization of the Human von Hippel-Lindau Disease Gene", Cancer Res. 1995, 55, 743-747.
Gebeyehu, G., et al., "Novel biotinylated nucleotide--analogs for labeling and colorimetric detection of DNA", Nucl. Acids Res. 1987, 15, 4513-4534.
Gelbert et al., "Analysis of GPT Activity in Mammalian Cells with a Chromosomall Integrated Shuttle Vector Containing Altered gpt Genes", Somat. Cell. Mol. Genet. 1990, 16, 173-184.
Gennaro, Alfonso, Ed., Remington's Pharmaceutical Sciences, 18th Edition 1990. Mack Publishing Co., Easton, PA.
Gold and Stormo in: Escherichia coli and Salmonella typhimurium: Cellular and Molecular Biology, vol. 2, 1987, Neidhardt et al. eds., American Society for Microbiology, Washington, D.C., p. 1302-1307.
Kabanov et al., "A new class of antivirals: antisense oligonucleotides combined with a hydrophobic substituent effectively inhibit influenza virus reproduction and synthesis of virus-specific proteins in MDCK Cells", FEBS Lett. 1990, 259, 327-330.
Kanagasundaram et al., "Isolation and characterization of the gene encoding gluconolactonase from Zymomonas mobilis", Biochim, Biophys. Acta 1992, 1171, 198-200.
Kornberg, A. DNA Replication, W.H. Freeman & Co., San Francisco, 1980, pp 75-77.
Leeds et al., "Quantitation of Phosphorothioate Oligonucleotides in Human Plasma", Anal. Biochem. 1996, 235, 36-43.
Leeds et al. Drug Metab. and Disp., in press.
Letsinger et al., "Cholesteryl-conjugated oligonucleotides: Synthesis, properties, and activity as inhibitors or replication of human immunodeficiency virus in cell culture", Proc. Natl. Acad. Sci. USA 1989, 86, 6553-6556.
McDermott et al., "Structure and lens expression of the gene encoding chicken .beta.A3/A1-crystallin", Gene 1992, 117, 193-200.
Manoharan et al., "Cholic Acid-Oligonucleotide Conjugates for Antisense Applications", Bioorg. Med. Chem. Let. 1994, 4, 1053-1060.
Manoharan et al., "Antisense Strategies", Ann. N.Y. Acad. Sci. 1992, 660, 306-309.
Manoharan et al., "Introduction of a Lipophilic Thioether Tether in the Minor Groove of Nucleic Acids for Antisense Applications", Bioorg. Med. Chem. Let. 1993, 3, 2765-2770.
Manoharan et al., "Oligonucleotide Conjugates: Alteration of the Pharmacokinetic Properties of Antisense Agents", Nucleosides & Nucleotides 1995, 14, 969-973.
Manoharan et al., "Lipidic Nucleic Acids", Tetrahedron Lett. 1995, 36, 3651-3654.
Markussen et al., "Translational control of oskar generates Short OSK, the isoform that induces pole plasma assembly", Development 1995, 121, 3723-3732.
Martin et al., "Ein neuer Zugang zu 2'-O-Alkylribonucleosiden und Eigenschaften deren Oligonucleotide", Helv. Chim. Acta 1995, 78, 486-504.
Mishra et al., "Improved leishmanicidal effect of phosphorotioate antisense oligonucleotides by LDL-mediated delivery", Biochim. Biophys. Acta 1995, 1264, 229-237.
Monaco et al., "Structure of Two Rate Genes Coding for Closely Related Rolipram-sensitive cAMP Phosphodiesterases", J. Biol. Chem. 1994, 269, 347-357.
Nielsen et al., "Sequence-Selective Recognition of DNA by Strand Displacement with a Thymine-Substituted Polyamide", Science 1991, 254, 1497-1500.
Oberhauser et al., "Effective incorporation of 2'-O-methyl-oligoribonucleotides into liposomes and enhanced cell association through modification with thiocholesterol", Nucl. Acids Res. 1992, 20, 533-538.
Olsen et al., "Inhibition of Protein Kinase-A by Overexpression of the Cloned Human Protein Kinase Inhibitor", Mol. Endocrinol. 1991, 5, 1246-1256.
Pari et al., "Potent Antiviral Activity of an Antisense Oligonucleotide Complementary to the Intron-Exon Boundary of Human Cytomegalovirus Genes UL36 and UL37", Antimicrob. Agents Chemother. 1995, 39, 1157-1161.
Perri et al., "Interactions of Plasmid-encoded Replication Initiation Proteins with the Origin of DNA Replication in the Broad Host Range Plasmid RK2", J. Biol. Chem. 1991, 266, 12536-12543.
Pushpa-Rekha et al., "Rat Phospholipid-hydroperoxide Glutathione Peroxidase", J. Biol. Chem. 1995, 270, 26993-26999.
Rogers et al., "Alternative splicing dictates translational start in Epstein-Barr virus transcripts", EMBO J. 1990, 9, 2273-2277.
Saison-Behmoaras et al., "Short modified antisense oligonucleotides directed against Ha-ras point mutation induce selective cleavage of the mRNA and inhibit T24 cells proliferation", EMBO J. 1991, 10, 1111-1118.
Sanghvi, Y. S. in Antisense Research and Applications, Crooke and Lebleu, eds., CRC Press, Boca Raton, 1993, pp. 276-278.
Saul et al., "celB, a Gene Coding for a Bifunctional Cellulase from the Extreme Thermophle "Caldocellum saccharolyticum"", Appl. Environ. Microbiol. 1990, 56, 3117-3124.
Shea et al., "Synthesis, hybridization properties and antiviral activity of lipid-oligodeoxynucleotide conjugates", Nucl. Acids. Res. 1990, 18, 3777-3783.
Svinarchuk et al., "Inhibition of HIV proliferation in MT-4 cells by antisense oligonucleotide conjugated to lipophilic groups", Biochimie 1993, 75, 49-54.
Yaoita et al., "Xenopus laevis .alpha. and .beta. thyroid hormone receptors", Proc. Natl. Acad. Sci. USA 1990, 87, 7090-7094.
Branch TIBS 23:45-50, Feb. 1998.
Flanagan et al. Nature Biotechnology 17:48-52, Jan. 1999.
Martin Helvetica Chimica Acta 78:486-504, 1995.
Bryant et al. J. Gen. Virol. 74:1965-1967, 1993.
Anderson Kevin P.
Chapman Sharon
Draper Kenneth G.
Kisner Daniel L.
Isis Pharmaceuticals , Inc.
McGarry Sean
Schwartzman Robert A.
LandOfFree
Composition and method for treatment of CMV infections does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Composition and method for treatment of CMV infections, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Composition and method for treatment of CMV infections will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1725966