Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1993-07-07
1994-08-23
Cintins, Marianne M.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514306, 514825, 514912, 514915, A61K 3144
Patent
active
053408217
ABSTRACT:
A composition for treating a Sjoegren syndrome disease is disclosed. The composition comprising derivative of spirooxathiolane-quinuclidine of the following formula (I), ##STR1## wherein Z is .dbd.CR.sup.1 R.sup.2, wherein R.sup.1 and R.sup.2 may be the same or different and each represents hydrogen, alkyl, cyclopentyl, cyclohexyl, aryl, diarylmethylol, or alkyl which may be substituted by one or more aryl groups, or an acid addition salt thereof, or an acid addition salt thereof, as an effective component. Especially effective is an administration of a hydrochloric acid addition salt of 2-methylspiro(1,3-oxathiolane-5,3')quinuclidine.
REFERENCES:
patent: 4001396 (1977-01-01), Feuer
patent: 4100271 (1978-07-01), Krezanoski
patent: 4110441 (1978-08-01), Feuer et al.
patent: 4701450 (1987-10-01), Kelder et al.
patent: 4782067 (1988-11-01), Blythin et al.
patent: 4976969 (1990-12-01), Plamondon
patent: 4997654 (1991-03-01), Corsello et al.
patent: 5162339 (1992-11-01), Lowe, III
patent: 5242927 (1993-09-01), Baker et al.
patent: 5242930 (1993-09-01), Baker et al.
H. B. Kaltreider, et al., "The Neuropathy of Sjogren's Syndrome", Annals of Internal Medicine, 70(4):751-762, 1969.
E. L. Alexander, et al., "Neurologic Complications of Primary Sjogren's Syndrome", Medicine, 61(4):247-257, 1982.
J. L. Konzelman, et al., "Xerostomia; Diagnosis and Treatment", U.S. Navy Medicine, 74, 16-18, 1983.
M. Navazesh, et al., "Xerostomia; Diagnosis and Treatment", Am. J. Otolaryngol, 4, 283-292, 1983.
R. I. Fox, et al., "Primary Sjogren's Syndrome; Clinical and Immunopathologic Features", Semin. Arthritis. Rheum., 14(2), 77-105, 1984.
R. T. Molina, et al., "Peripheral Inflammatory Vascular Disease In Sjogren's Syndrome", Arthritis and Rheumatism, 28(12), 1341-1347, 1985.
R. Manthorpe, et al., "Treatment of Sjogren's Syndrome; An Overview", Scand. J. Rheumatol. Suppl., 61, 237-241, 1986.
L. M. Sreebny, et al., "Xerostomia; A Neglected Sympton", Arch. Intern. Med., 147(7), 1333-1337, 1987.
H. M. Moutsopoulos, et al., "New Developments in Sjogren's Syndrome", Curr. Opin. Rheumatol., 1(3), 332-338, 1989.
K. J. Bloch, et al., "Classics in Medicine", 71(6), 386-403, 1992.
A. Fisher, et al., "AF102B, A Novel Putative M1 Agonist As A Candidated Drug For Treatment of Alzheimer's Disease", International Symposium on Muscarinic Functions (Nov. 30-Dec. 4), 1986.
A. Fisher, et al., "AF102B A Novel Putative M1 Agonist Reverses AF64A-Induced Cognitive Impairments In Rats", Soc. Neurosci Abstr., 12 702, 1986.
A. Fisher, et al., "AF102B A Novel M1 Muscarinic Agonist A A Potential Drug For The Treatment of Alzheimer's Disease", Proceedings of the 4th Meeting of the International Study Group on the Pharmacology of Memory Disorders Associated with Aging (Jan. 16-18), 1987.
N. Nakahara, et al., "Single and Repeated Adminstration of AF102B, A Novel Muscarinic Agonist Improve Cognitive Dysfunctions in AF64A-Treated Rats", Soc. Neurosci. Abstr., 13, 837, 1987.
A. Fisher, et al., "AF102B A New M1 Agonist with Potential Application In Alzheimer's Disease", Soc. Neurosci. Abstr., 13, 657, 1987.
N. Nakahara, et al., "Effects of Intracerebroventricular Injection of Af64A On Learning Behaviors In Rats", Japan J. Pharmacol., 48(4), 121-130, 1988.
N. Nakahara, et al., "Amelioration of Experimental Amnesia (Passive Avoidance Failure) In Rodents By The Selective M1 Agonist AF102B": Japan J. Pharmacol., 48(4), 502-506, 1988.
S. Ono, et al., "Heterogeneity of Muscarinic Autoreceptors and Heteroreceptors In The Rat Brain; Effects of Novel M1 Agonist", AF102B: European J. Pharmacol., 155(1/2), 77-84, 1988.
F. Mizobe, et al., "AF102B A Novel Muscarinic M1 Type Agonist, Stimulated Presynaptic Auto- and Heteroreceptors In Different Potency", Trends In Pharmacol. Sci., 9(Suppl.), 81, 1988.
H. Kobayashi, et al., "Dual Type of M1 Muscarinic Effects of Selective Agonists Af102B and McN-A343 on Synaptic Gangia", Trends In Pharmacol. Sci., 9(Suppl.), 1988.
S. Mochida, et al., "Stimulation of M2-Muscarnic Receptor Decreases Calcium Entry During Action Potential", Trends In Pharmacol. Sci., 9(Supp.), 1988.
S. Hochik, et al., "Comparative Studies on Mutagenicity of Muscarnic Agonists", Mutation Res., 230, 374, 1988.
A. Fisher, et al., "AF102B A Potential Drug For The Treatment of Alzheimer's Disease (AD); Further Characterization", Soc. Neurosci. Abstr., 14, 905, 1988.
Y. Iga, et al., "SND-5008 (AF102B), A Novel Muscarinic Agonist, Improves Experimental Cognitive Dysfunctions In Rodents", Soc. Neurosci. Abstr. 14, 57, 1988.
S. Moshida, et al., "Dual Synaptic Effects of Activating M1-Muscarinic Recepotrs, In Superior Cervical Ganglia of Rabbits", Brain Research, 455, Sep. 17, 1988.
Mann Xu, et al., "Differential Effects of M1- and M2-Muscarnic Drugs on Striatal Dopamine Release and Metabolism In Freely Moving Rats": Brain Res., 495(2), 232-242, 1989.
N. Nakahara, et al., "Beneficial Effects of a Selective M1-Agonist AF102B On Experimental Models In A Possessive Avoidance Task": Japan J. Pharmacol., 49(Suppl.), 271, 1989.
M. Yoshioka, et al., "Effect of a Novel Muscarinic Receptor Agonist, AF102B, On Cardiac Sympathetic Nerve Activity In Anesthetized Rats": Japan. J. Pharmacol. 49(Suppl.), 271, 1989.
N. Nakahara, et al., "Beneficial Effects of FKS-508 (AF102B), a Selective M1 Agonist, On The Impaired Working Memory in AF64A-Treated Rats: Japan J. Pharmacol.," 51(4), 539-547, 1989.
A. Fisher, et al., "A New M1 Agonist As A Rational Strategy In Alzheimer's Disease", Alzheimer's and Parkinson's Diseases, The Second International Conference (Nov. 6-10), Kyoto, 1989.
F. Mizobe, et al., "FKS-508 (AF102B), A Novel M1 Agonist, Ameliorates Experimental Amnesia in AF64A-Treated Rats", Alzheimer's and Parkinson's Diseases, The Second International Conference (Nov. 6-10, Kyoto, 1989.
T. Kato, et al., "M1 Receptors Stimulate Dopamine Release Via Protein Kinase C In The Striatum of Freely Moving Rats Studies with Brain Dialysis", Alzheimer's and Parkinson's Diseases, The Second International Conference (Nov. 6-10), Kyoto, 1989.
A. Fisher, et al., "AF102B A New M1 Agonist Attenuates Cognitive Dysfunctions In AF64A-Treated Rats", Neurosci. Letters, 102(2-3), 325-331, 1989.
F. Mizobe, et al., "AF102B A Selective M1 Agonist As A Potential Drugs For The Treatment of Senile Dementia Of The Alzheimer Type", Proceedings of the Fifth Meeting of the International Study Group On The Pharmacology of Memory Disorders Associated with Aging, Zurich, Switzerland, Jan. 20-22, 1989.
A. Fisher, et al., "AF102B A Rational Treatment Strategy In Alzheimer's Disease (AD) Recent Advances", Proceedings of the Fifth Meeting of the International Study Group on the Pharmacology of Memory Disorders Associated with Aging, Zurich, Switerland, Jan. 20-22, 1989.
A. Fisher, et al., "AF102B Rational Treatment Strategy in Alzheimer's Disease (AD); Recent Advances", Adv. Neurol., 51, 257-259, 1990.
N. Nakamura, et al., "Central Muscarinic Activities of M1-Selective Agonist; Preferential Effect On Reversal of Amnesia", Brain Research 507(1), 172-175, 1990.
R. Brandeis, et al., "Reversal of Age-Related Cognitive Impairments By M1 Cholinergic Agonist AF102B", Pharmacol. Biochemi. Behav., 36(1), 89-95, 1990.
Z. Pittel, et al., "Distinct Muscarinic Receptor Subtypes Differentially Modulate Acetylcholine Release From Corticocerebral Synaptosomes": J. Neurochem., 001-008, 1990.
N. Ogane, et al., "Effects of a M1 Receptor Agonist On The Central Cholinergic System, Evaluated By a Brain Microdialysis", Neurosci Letters, 114, 95-100, 1990.
M. Yoshioka, et al., "Symphathoexcitatory Action Of A Novel Muscarine Receptor Agonist, AF102B, And Its Blockade By Pirenzapine", Pharmacol. & Toxicol., 67, 84-87, 1990.
H. Togashi, et al., "Effects of a Novel Cholinergic M1 Agonist AF102B, On Ambulation And Water Drinking Behavior In Rats", Hokkaido J. Med. Sci. 66(1), 59-66, 1990.
A. Fisher, et al., "New Muscarini Agonists With Special Emphasis On AF102B", Sec. Int. Springfield Symposium Adv. Alzheimer Therapy, Abstract, 1991.
Y. Iga, et al., "AF102B Preclinical Experience", Sec. Int. Springfield Symposium Adv. Alzheimer
Abe Nobuaki
Takeshita Yasuyoshi
Cintins Marianne M.
Criares T. J.
Snow Brand Milk Products Co. Ltd.
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