Composition and method for treating glaucoma

Details Composition and method for treating glaucoma Composition and method for treating glaucoma

1977-01-27

1978-11-21

Meyers, Albert T.

Drug, bio-affecting and body treating compositions

Nonspecific immunoeffector, per se ; or nonspecific...

Lipid or oil

A61K 3135

Patent

active

041266943

ABSTRACT:
Tetrahydrodibenzopyrans having the structure ##STR1## in which R, R.sub.1, and R.sub.2 are alkyl having from 1 to 4 carbon atoms and ophthalmologically acceptable acid addition salts thereof are effective anti-glaucoma agents, free from all but a very small amount of CNS activity, when applied topically.

REFERENCES:
patent: 3668224 (1972-06-01), Petrzilka
patent: 3728360 (1973-04-01), Pars et al.
patent: 3734930 (1973-05-01), Razdan et al.
patent: 3799946 (1974-03-01), Loev
patent: 3920809 (1975-11-01), Thakkar
patent: 4025536 (1977-05-01), Korte et al.
Ophthalmologica 168, 366-369 (1974) D. Shapiro . . . The Ocular Manifestations of the Cannabinols . . . Newsweek, Nov. 8, 1976, Pot and Glaucoma.
Chem. Abst. 83 158,044(r) (1975)-Purnell et al. ".DELTA..sup.9 -Tetrahydrocannabinol . . . in Man".
Chem. Abst. 84 130,270(h) (1976) Green et al., "Interaction of Tetrahydrocannabinol in the Eye".

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