Composition and method for treating cancer using herpes virus

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Recombinant virus encoding one or more heterologous proteins...

Reexamination Certificate

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C424S229100, C435S320100

Reexamination Certificate

active

10477444

ABSTRACT:
The present invention provides a herpes virus in which a non-essential gene for replication is inactivated More particularly, the present invention provides a herpes virus in which a non-essential gene for replication present in a UL or US region is inactivated. More preferably, the non-essential gene for replication contains US3 or UL56. The herpes virus may be preferably a herpes simplex virus, and more preferably herpes simplex virus 1 or herpes simplex virus 2. The present invention provides a method, composition and use for treating various diseases or disorders including tumor and infectious diseases. The present invention also provides a method, composition and use for activating a prodrug.

REFERENCES:
patent: 5837532 (1998-11-01), Preston et al.
patent: 5922328 (1999-07-01), Spector et al.
patent: 6641817 (2003-11-01), Coffin et al.
patent: WO96/04394 (1996-02-01), None
patent: WO98/42195 (1998-10-01), None
Pyles, R.B. and Thompson, R.L., “Evidence that the Herpes Simplex Virus Type 1 Uracil DNA Glycosylase is Required for Efficient Viral Replication and Latency in the Murine Nervous System”, Journal of Virology, vol. 68, No. 8, Aug. 1994, pp. 4963-4972.

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