Composition and method for transplantation therapy

Details Composition and method for transplantation therapy Composition and method for transplantation therapy

1982-10-18

1984-12-25

Apley, Richard J.

Surgery

Truss

Perineal

424 85, C07G 1700, C07G 700, C07G 1100, A61K 3900

Patent

active

044897103

ABSTRACT:
An improved transplantion therapy and method is provided which comprises specifically killing cells known to be problematic in the transplantion process. Novel compositions of the present invention are conjugates prepared by generating antibodies specific to surface receptors of the unwanted cells, preparing Fab or F(ab').sub.2 fragments from the antibodies, and coupling the fragments to A chains of lectins or other cytotoxic agents to render the conjugates thus formed strongly cytotoxic to the cells to which the antibody was directed. The conjugates are used in vitro to eliminate unwanted cells prior to bone marrow transplantation.

REFERENCES:
W. Muller--Ruchholtz, et al., Transplantation Proceedings, vol. VIII pp. 537-541, 12/1976.
Reinherz, et al., The Journal of Immunology, vol. 123, No. 3, pp. 1312-1317, 9/1979.
Reisner, et al., Proc. Natl. Acad. Sci., vol. 77, No. 2, pp. 1164-1168, 2/1980.
Youle, et al., Proc. Natl. Acad. Sci., vol. 77, No. 9, pp. 5483-5486, 9/1980.
Raso, et al., J. of Immunology, vol. 125, pp. 2610-2616, 12/1980.

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