Composition and method for transdermal delivery of diclofenac

Details Composition and method for transdermal delivery of diclofenac Composition and method for transdermal delivery of diclofenac

1993-03-16

1994-12-20

Phelan, D. Gabrielle

Drug, bio-affecting and body treating compositions

Designated organic nonactive ingredient containing other...

Solid synthetic organic polymer

514944, 514946, 514887, A01N 2500

Patent

active

053746619

ABSTRACT:
The topical drug delivery composition and method of the present invention provides a composition and method for delivering amounts of diclofenac effective for treating inflamed and/or painful joints or muscles percutaneously via a gel. Diclofenac sodium is solubilized in a mixture of water, a low molecular weight alcohol, and a glycol. In the present invention, the transdermal flux of diclofenac is unexpectedly enhanced by the addition of an ether alcohol and a fatty alcohol ester. The transdermal flux can be further enhanced by the addition of a glycol such as hexylene glycol.

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