Organic compounds -- part of the class 532-570 series – Organic compounds – Fatty compounds having an acid moiety which contains the...
Patent
1990-05-29
1992-05-26
Dees, Jose G.
Organic compounds -- part of the class 532-570 series
Organic compounds
Fatty compounds having an acid moiety which contains the...
554156, 554157, C11C 314
Patent
active
051165457
ABSTRACT:
The major component of the carbonate fraction of free acids extractable from alfalfa has shown excellent control of symptoms in patients with sickle cell disease. Its structure has been established by proton NMR spectrometry as beign 16-hydroxy-9Z,12Z,14E-octadecatrienoic acid and closely related compounds, such as simple esters, amides, triglycerides, or other derivatives of the carboxylic acid function, and a method for its synthesis from linseed oil or methyl linolenate has been developed. The product from linseed oil, both in the form of the initially formed triglyceride and in the form of its free acid obtained by saponification, is useful for the treatment of sickle cell disease.
REFERENCES:
patent: 3102891 (1963-09-01), Allen
patent: 4473559 (1984-09-01), Robinson
Van Dijk et al, Chemical Abstracts, vol. 98, p. 103 1983, 128123k.
JP 81/75,481, Chemical Abstracts, vol 95, p. 635 1981, 187046w.
Elujoba and Sofowora, "Detection and Estimation of Total Acid in the Antisickling Fraction of Fagara Species," Planta Medica, 32:54-59 (1977).
Fadulu, "Ethyl-Alcohol Extract from Fagara Zanthoxyloides Root: Invitro Effect on Red Blood Cells," Faculty Research Journal, Texas Southern Univ., 1:20-31 (1977).
Isaacs-Sodeye, et al., "Extract of Fagara Zanthoxyloides Root in Sickle Cell Anemia," Acta Haemat., 53:158-164 (1975).
Sofowara and Isaacs, "Reversal of Sickling and Crenation in Erythrocytes by the Root Extract of Fagara Zanthoxyloides," Lloydia, 34:383-385 (1971).
Sofowara, et al., "Isolation and Characterisation of an Antisickling Agent from Zanthoxyloides Root", Lloydia, 38:169-171 (1975).
Carr Deborah D.
Dees Jos,e G.
Omex International, Inc.
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