Composition and method for testing to predict and/or diagnose al

Drug – bio-affecting and body treating compositions – In vivo diagnosis or in vivo testing – Magnetic imaging agent

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424 12, 424271, 548201, A61K 2900, A61K 3143

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active

042281474

ABSTRACT:
The invention relates to the testing of humans or other animals, such as horses, cattle or dogs, for allergic reaction or hypersensitivity to penicillins. The tests can be used both to predict and to diagnose allergy. The invention comprises new penicilloyl-polylysine (PPL) preparations, new materials for use in minor determinant mixture (MDM) compositions and novel test methods employing such materials.
The new PPL preparations comprise homogeneous, high purity, maximally coupled, .alpha.-diastereoisomeric, penicilloyl conjugates of low molecular weight PPLs. The PPL materials of the invention have the molecular structure in accordance with the following generic formula: ##STR1## wherein: R is selected from the group consisting of H and penicilloyl groups or similar groups derived from cephaolosporins or other .beta.-lactam antibiotics; and

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patent: 3804820 (1974-04-01), Quitt
patent: 3867365 (1975-02-01), Stohmann
patent: 3979508 (1976-09-01), Stohmann
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Levine, II, Int. Arch. Allergy, 35, 445 (1969).
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Zukowski et al., Chem. Abs. 86, No. 72508, (1976).
Clarke, et al, Chemistry of Penicillin, 1949, pp. 554-556.
Levine, IV, J. of Clin. Invest., vol. 47, Mar. 1968, pp. 556-566.

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