Composition and method for stabilizing radiolabeled compounds us

Details Composition and method for stabilizing radiolabeled compounds us Composition and method for stabilizing radiolabeled compounds us

1982-07-12

1983-10-25

Nucker, Christine M.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

436 8, 436 18, 252644, A61K 4300, A61K 4900

Patent

active

044118813

ABSTRACT:
A stabilized composition comprising a solution of a radiolabeled compound and a diethylenetriamine is described. Preferred diethylenetriamines include, N,N-bis(2-aminoethyl) dithiocarbamic acid, di(2-dithiocarbamyl-ethyl) amine, and salts thereof.

REFERENCES:
patent: 3876550 (1975-04-01), Holubee
patent: 3919095 (1975-11-01), Okorodudu
patent: 4358434 (1982-11-01), Tzodikov et al.
"Synthesis and Antiradiation Properties of Polymeric Dithiocarbamates", V. S. Etlis et al., UDC 615.849.1.015.25:547.496.2, translated from Khimiko-Farmatsevticheskii Zhurnal, vol. 10, No. 4, pp. 33-35, Apr. 1976.
"Synthese et Effets Radioprotecteurs d'Alkanebisdithiocarbamates disodiques, d'Acides .omega.-Aminoalkyldithiocarbamiques et de leurs derives N,N'-Dimethyles," J. H. Barnes et al., Eur. J. Med. Chem. Chimca Therapeutica, Nov.-Dec. 1975, 10 N.degree. 6, pp. 619-622.

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