Composition and method for reducing adverse interactions...

Details Composition and method for reducing adverse interactions... Composition and method for reducing adverse interactions...

2006-03-07

2006-03-07

Maier, Leigh C. (Department: 1623)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

C514S225200, C514S225500, C514S226200

Reexamination Certificate

active

07008934

ABSTRACT:
Compositions and methods are provided for reducing adverse reactions as a result of parenteral administration of certain phenothiazine derivatives such as promethazine hydrochloride. The active compound may be admixed with an effective amount of one or more cyclodextrin derivatives, and if desired, one or more non-ionic surfactants such as the partial esters of sorbitol and the polyoxyethylene oxides of long chain fatty acids such as the polysorbates.

REFERENCES:
Uekama, K. et al “Protective effects of cyclodextins . . . ” J. Pharm. Dyn. (1981) vol 4, pp 142-144.

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