Drug – bio-affecting and body treating compositions – Radionuclide or intended radionuclide containing; adjuvant...
Patent
1988-01-29
1989-12-26
Maples, John S.
Drug, bio-affecting and body treating compositions
Radionuclide or intended radionuclide containing; adjuvant...
252625, 252644, 128654, 600 3, A61K 4300, A61B 600
Patent
active
048897078
ABSTRACT:
Radioactive microspheres for radiation synovectomy of arithmetic joints in a mammal comprise a biodegradable glass material and a beta radiation emitting radioisotope chemically dissolved in and distributed substantially uniformly throughout the glass material. The biodegradable glass material may be lithium silicate, lithium aluminosilicate, lithium aluminoborate, lithium germanate, lithium aluminogermanate, potassium silicate, potassium aluminosilicate, potassium, aluminoborate, potassium germanate or potassium aluminogermanate and the beta radiation emitting radioisotope may be samarium-153, holmium-166, erbium-169, dysprosium-165, rhenium-186, rhenium-188 or yttrium-90. Methods for preparing such microspheres and for carrying out radiation synovectomy of arthritic joints utilizing such microspheres are also disclosed.
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Radcliffe, J. H. et al., "Albumin Microspheres for Intra-Articular Drug Delivery", J. Pharm. Pharmacol., 39(4), 290-5 [C.A. 106(22): 182574].
Day Delbert E.
Ehrhardt Gary J.
Maples John S.
The Curators of the University of Missouri
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