Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Reexamination Certificate
2011-05-17
2011-05-17
Kelly, Robert M (Department: 1633)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
Reexamination Certificate
active
07943569
ABSTRACT:
The present invention is a composition for providing localized delivery of a therapeutic agent to a subject. The instant composition is a hydrophilic matrix-based prodrug system, wherein a protease substrate peptide acts as extracellular protease degradable spacer binding the therapeutic agent to a hydrophilic matrix. Release of the therapeutic agent is achieved by localized activity of extracellular proteases thereby providing minimal toxicity of the therapeutic agent and maximum release with protease activity. Methods for producing the instant composition and providing localized delivery of a therapeutic agent to a subject are also provided.
REFERENCES:
patent: 3867329 (1975-02-01), Halpern et al.
patent: 5514379 (1996-05-01), Weissleder et al.
patent: 6224903 (2001-05-01), Martin et al.
patent: 6844318 (2005-01-01), Copeland et al.
patent: 2002/0103133 (2002-08-01), Copeland et al.
patent: 2003/0195152 (2003-10-01), Suarato et al.
patent: 2004/0001892 (2004-01-01), Healy et al.
patent: 2004/0116348 (2004-06-01), Chau et al.
patent: 2004/0228831 (2004-11-01), Belinka et al.
patent: WO 0168145 (2001-09-01), None
patent: 02072620 (2002-09-01), None
patent: 2007103364 (2007-09-01), None
Duncan, Ruth, “The Dawning Era of Polymer Therapeutics”, Nature Reviews 2003 2:347-360.
Kost et al., “Responsive polymeric delivery systems”, Advanced Drug Delivery Reviews 2001 46:125-148.
Moses et al., “Advancing the field of drug delivery: Taking aim at cancer”, Cancer Cell 2003 4:337-341.
Peppas et al., “Poly(ethylene glycol)-containing hydrogels in drug delivery”, Journal of Controlled Release 1999 62:81-87.
Turk et al., “Determination of protease cleavage site motifs using mixture-based oriented peptide libraries”, Nature Biotechnology 2001 19:661-667.
Gemeinhart Richard A.
Tauro Jovita R.
Kelly Robert M
Licata & Tyrrell P.C.
The Board of Trustees of the University of Illinois
LandOfFree
Composition and method for providing localized delivery of a... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Composition and method for providing localized delivery of a..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Composition and method for providing localized delivery of a... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2626313