Composition and method for preventing or treating a virus...

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Conjugate or complex

Reexamination Certificate

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C424S196110, C424S209100, C530S403000

Reexamination Certificate

active

07740860

ABSTRACT:
The present invention provides multiple antigenic agents compositions and the use thereof to prevent or treat viral infections.

REFERENCES:
patent: 7354589 (2008-04-01), Gerhard et al.
patent: 7527798 (2009-05-01), Gerhard et al.
patent: WO 97/38011 (1997-10-01), None
Mozdzanowska et al (Vaccine 21:2616-2626, 2003).
Kragol et al (Bioorganic & Medicinal Chemistry Letters 11:1417-1420, 2001).
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Fiers et al., “Soluble recombinant influenza vaccines”, Phil. Trans. R. Soc. Lond. B 2001 356:1961-1963.
Gerhard et al., “Identification of Eight Determinants in the Hemagglutinin Molecule of Influenza Virus A/PR/8/34 (H1N1) Which Are Recognized by Class II-Restricted T Cells from BALB/c Mice”, J. Virology 1991 65(1):364-372.
Heinen et al., “Vaccination of pigs with a DNA construct expressing an influenza virus M2-nucleoprotein fusion protein exacerbates disease after challenge with influenza A virus”, J. General Virology 2002 83:1851-1859.
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Zaliauskiene et al., “Enhancement of MHC Class II—Restricted Responses by Receptor-Mediated Uptake of Peptide Antigens1”, J. Immunol 2002 169:2337-2345.
Kragol et al., “Synthesis of a Disulfide-Linked Octameric Peptide Construct carrying Three Different Antigenic Determinants”, Bioorganic & Medicinal Chemistry Letters 2001 11:1417-1420.
Kragol et al., “Orthogonal solid-phase synthesis of tetramannosylated peptide constructs carrying three independent branched epitopes”, Tetrahedron 2001 57:957-966.
Mozdzanowska et al., “Induction of influenza type A virus-specific resistance by immunization of mice with a synthetic multiple antigenic peptide vaccine that contains ectodomains of matrix protein 2”, Vaccine 2003 21:2616-2626.
Kragol et al., “Orthogonal solid-phase synthesis of tetramannosylated peptide constructs carrying three independent branched epitopes”, Tetrahedron 2001 57:957-966.
Kragol et al., “Synthesis of a Disulfide-Linked Octamerie Peptide Construct Carrying Three Different Antigenic Determinants”, Bioorganic & Medicinal Chemistry Letters 2001 11:1417-1420.
Tamura et al., “Acceleration of Influenza Virus Clearance by Th1 Cells in the Nasal Site of Mice Immunized Intranasally with Adjuvant-Combined Recombinant Nucleoprotein”, Journal of Immunology 1996 156:3892-3900.

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