Composition and method for preventing and treating inflammation

Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,...

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4241841, 5303871, 530861, 530868, A61K 39395, C07K 1606

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active

058339841

ABSTRACT:
Inflammation can be treated or prevented altogether by administering a preparation comprising IgA. These preparations also can effect immunomodulation. Preferably, the preparation includes multimeric IgA and is essentially free of IgG in its various forms. Other compounds, such as antibiotics, antiphlogistic agents and antacids, also may be administered. Immunoglobulin A may also be used in vaccines to prevent inflammation. Additionally, an improved assay for evaluating anti-inflammatory activity is provided.

REFERENCES:
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EiBL et al., Journal of Clinical Immunology, vol. 10, No. 6 (Nov. Supp. 1990) pp. 725-795.
Peeters et al. Annals of the Rheumatic Diseases, vol. 49. pp. 636-640.
Takei et al. J. Clin. Invest., vol. 91, pp. 602-607 (Feb. 1993).
Boyum, The Scandinavian Journal of Clinical & Laboratory Investigation, vol. 21, Suppl 97, pp. 77-89 (1968).
Kabat et al., Experimental Immunochemistry, Second Edition, Fourth Printing, pp. 133-157 (Jan. 1971).
Male, et al., Advanced Immunology, J.B.Lippincott Co., Philadelphia, pp. 16, 18, 1990.
The Sigma ImmunoChemicals Catalog, 1990, pp. 181-182.
Barron et al., J. Rhematology, 1992, 19(Suppl 33):94.
Physicians Desk Reference, 1990, Sandoz Product Information.

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