Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Halogenated hydrocarbon doai
Patent
1983-07-08
1985-07-23
Robinson, Douglas W.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Halogenated hydrocarbon doai
514909, A61K 31025
Patent
active
045309361
ABSTRACT:
A method of inhibiting the absorption of nutritional elements, principally food, from the gastrointesinal tract is disclosed which comprises ingesting perfluorodecalin in an amount sufficient to form a nutritional element-impermeable film thereof on at least a substantial part of the inner wall of the upper intestine and maintaining the film for a time long enough to inhibit the absorption from the gastrointestinal tract of a significant proportion of the ingested nutritional elements. An emulsion dosage form is preferred for carrying out this method, which emulsion contains perfluorodecalin, water, and a non-toxic emulsifier, preferably Pluronic F-68, and optionally flavoring and/or coloring agents.
REFERENCES:
patent: 3962439 (1976-06-01), Yokoyama et al.
patent: 4423077 (1983-12-01), Slouter
Perfluoroocytyl Bromide: A Potential Antiobesity Compound, Journal of Pharmaceutical Sciences, vol. 66, No. 6, p. 907, (Jun. 1977).
Perfluorodecalin as a Red Cell Substitute from Blood Substitutes and Plasma Expanders, pp. 69-80, Alan R. Liss, Inc., New York, N.Y., 1978.
Clinical Studies of a Perfluorochemical Whole Blood Substitute (Fluosol-DA), by Misuno et al., pp. 60-69 of vol. Whole Blood Substitute, J. B. Lippincott Company, Ann. Surg., Jan. 1982.
Farmacon Research Corporation
Robinson Douglas W.
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