Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Food or edible as carrier for pharmaceutical
Patent
1994-06-21
1998-05-19
Spear, James M.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Food or edible as carrier for pharmaceutical
424469, 424489, 424490, 424494, 424497, 514909, 514910, 514937, 514951, A61K 910, A61K 914, A61K 926, A61K 31195
Patent
active
057532532
ABSTRACT:
A composition and method for the control of appetite having food grade nutrients as the active ingredients, and a pharmaceutically acceptable delivery agent, formulated so that the active ingredient is released predominantly in the ileum. The active ingredient may include sugars, fatty acids, polypeptides, and amino acids. The delivery agent may be a pH sensitive coating, a cellulosic polymer coating or a diazotized polymer. The composition may be formulated into pellets of between 1 and 3 mm with a density of around 1.0. The composition may be administered with a liquid as a slurry, or it may be administered in a tablet form. The composition may be used in conjunction with any weight loss or weight maintenance program.
REFERENCES:
Comparisons of the Effects on Satiety and Eating Behavior of Infusion of Lipid into the Different Regions of the Small Intestine; I. McL. Welch, C.P. Sepple & N.W. Read; Gut, vol. 29, pp. 306-311 (1988).
Regulation of Gastric Emptying by Ileal Nutrients in Humans; I. McL. Welch, K.M. Cunningham, & N.W. Read; Gastroenterology, vol. 94, pp. 401-404 (1988).
Further Characterisation of the 'Ileal Brake' Reflex in Man--Effect of Ileal Infusion of Partial Digest of Fat, Protein, and Starch On Jejunal Motility And Release Of Neurotensin, Enteroglucagon, and Peptide YY; R.C. Spiller, et al.; Gut, vol. 29, pp. 1042-1051 (1988).
The Ileal Brake--Inhibition of Jejunal Motility After Ileal Fat Perfusion in Man; R.C Spiller, et al.; Gut, vol. 25, pp. 365-374 (1984).
Effects of Ileal Infusions of Nutrients on Motor Patterns of Canine Small Intestine; Marie-Luise Siegle, American Physiological Society, pp. G78-G85; 1990.
Effect of Ileal Infusion of Intralipid on Gastrointestinal Transit, Ileal Flow Rate, and Carbohydrate Absorption in Humans After Ingestion Of a Liquid Meal, A.M. Holgate and N.W. Read; Gastroenterology, vol. 88, pp. 1005-1011 (1988).
Effect of Infusion of Nutrient Solutions Into The Ileum on Gastrointestinal Transit and Plasma Levels of Neurotensin and Enteroglucagon; N.W. Read, et al.; Gastroenterology, vol. 86, pp. 274-280; (1984).
The Ileal Brake--Inhibition of Jejunal Motility after Ileal Fat Perfusion in Man; R.C Spiller, et al.; pp. 365-374; Jul. 25, 1983.
Effect of Ileal Infusion of Glycochenodeoxycholic Acid on Segmental Transit, Motility, and Flow in the Human Jejunum and Ileum; R. Penagini, et al.; Gut, vol. 30, pp. 609-617 (1988).
The Effect of Terminal Ileal Triglyceride Infusion on Gastroduodenal Motility and The Intragastric Distribution of a Solid Meal; David R. Fone, et al.; Gastroenterology, vol. 98, pp. 568-575 (1990).
V.J. Burley, et al., "An Investigation of a Sugar Beet Fibre-Supplemented Breakfast on Energy Intake in Young Non-Obese Subjects," Abstract, International Journal of Obesity, (1992), 16, Suppl. 1, p. 53.
V.J. Burley, et al., The Effect of High and Low-Fibre Breakfasts on Hunger, Satiety and Food Intake in a Subsequent Meal, Int'l. Journal of Obesity (1987) 11, Suppl. 1, pp. 87-93.
V.J. Burley, et al., Influence of a High-Fibre Food (Myco-Protein) on Appetite: Effects on Satiation (with in Meals) and Satiety (Following Meals), European Journal of Clinical Nutrition (1993), 47, pp. 409-418.
Resit S. Canbeyli, et al., "The Role of Jejunal Signals in the Long-Term Regulation of Food Intake in the Rat," Physiology & Behavior, vol. 33, 1984, pp. 945-950.
Resit S. Canbeyli, et al., "Comparison of Gastric, Duodenal and Jejunal Contributions to the Inhibition of Food Intake in the Rat," Physiology & Behavior, vol. 33, 1984, pp. 951-957.
P.R. Ellis, et al., "Guar Bread: Acceptability and Efficacy Combined, Studies on Blood Glucose, Serum Insulin and Satiety in Normal Subjects," Br. J. Nutr. (1981), 46, pp. 267-276.
Stephen J. French et al., "Effect of Guar Gum on Hunger and Satiety After Meals of Differing Fat Content: Relationship with Gastric Emptying," Am. J. Clin. Nutr. 1994; 59, pp. 87-91.
S.H.A. Holt et al., "Particle Size, Satiety and the Glycaemic Response," European Journal of Clinical Nutrition (1994) 48, pp. 496-502.
Marcin Krotkiewski, "Effect of Guar Gum on Body-Weight, Hunger Ratings and Metabolism in Obese Subjects," British Journal of Nutrition (1984), 52, pp. 97-105.
Peter Leathwood, et al., "Effects of Slow Release Carbohydrates in the Form of Bean Flakes on the Evolution of Hunger and Satiety in Man," Appetite, 1988, 10, pp. 1-11.
H.C. Lin, et al., "Sustained Slowing Effect of Lentils on Gastric Emptying of Solids in Humans and Dogs," Gastroenterology (1992); 102, pp. 787-792.
H.C. Lin, et al., "Gastric Emptying of Solid Food Is Most Potently Inhibited by Carbohydrate in the Canine Distal Ileum," Gastroenterology (1992); 102, pp. 793-801.
Carol A. Maggio, et al., "Satiety in the Obese Zucker Rat: Effects of Carbohydrate Type and Acarbose (Bay g 5421)," Physiology & Behavior, vol. 46, 1989, pp. 557-560.
James H. Meyer, et al., "Effect of Size and Density on Canine Gastric Emptying of Nondigestible Solids," Gastroenterology (1985), 89, pp. 805-813.
J.H. Meyer, et al., "Effects of Viscosity and Fluid Outflow on Postcibal Gastric Emptying of Solids," American J. Physiol. 250, 1986, G161-G164.
J.H. Meyer, et al., "Human Postprandial Gastric Emptying of 1-3-Millimeter Spheres," Gastroenterology (1988), 94, pp. 1315-1325.
James H. Meyer, et al., "Intragastric vs. Intraintestinal Viscous Polymers and Glucose Tolerance After Liquid Meals of Glucose," Am. J. Clin. Nutr., 1988, 48, pp. 260-266.
James H. Meyer, et al., "GI Transit and Absorption of Solid food: Multiple Effects of Guar," Am. J. Clin. Nutr. 1988; 48, pp. 267-273.
Olaf Mickelsen, et al., "Effects of a High Fiber Bread Diet on Weight Loss in College-Age Males," American Journal of Clinical Nutrition 32; Aug. 1979, pp. 1703-1709.
D. Rigaud, et al., "Effects of a Moderate Dietary Fibre Supplement on Hunger Rating, Energy Input and Faecal Energy Output in Young, Healthy Volunteers," Int'l. Journal of Obesity (1987) 11, Suppl. 1, pp. 73-78.
Stephan Rossner, et al., "Weight Reduction with Dietary Fibre Supplements," Acta Med. Scand. 1987; 222; pp. 83-88.
Paul J. Sirois, et al., "Gastric Emptying of Nondigestible Solids in Dogs: a Hydrodynamic Correlation," Am. J. Physiol. 258, (1990), pp. G65-G72.
A. Tournier, et al., "Effect of the Physical State of a Food on Subsequent Intake in Human Subjects," Appetite, 1991, 16, pp. 17-24.
Jaakko Tuomilehto, et al., "Effect of Guar Gum on Body Weight and Serum Lipids in Hypercholesterolemic Females," Acta Med Scand 208 (1980), pp. 45-48.
Johan M.M. van Amelsvoort, et al., "Amylose-Amylopectin Ratio in a Meal Affects Postprandial Variables in Male Volunteers," Am. J. Clin. Nutri. 1992; 55, pp. 712-718.
N.J. Brown, et al., "Gastrointesetinal Adaptation to Enhanced Small Intestinal Lipid Exposure," Gut, Oct. 1994, vol. 35, No. 10, pp. 1409-1412.
Satiety Role of the Small Intestine Examined in Sham-Feeding Rhesus Monkeys; James Gibbs, S.P. Maddison & E.T. Rolls; Journal of Comparative and Physiological Psychology, vol. 95, No. 6, pp. 1003-1015., Jan. 12, 1981.
Intestinal Satiety in Rats; David S. Liebling, John D. Eisner, James Gibbs, and Gerald P. Smith; Journal of Comparative and Physiological Psychology, vol. 89, No. 8, pp. 955-965 Oct. 25. 1974.
Intraduodenal Infusions of Fats Elicit Satiety in Sham-Feeding Rats; Danielle Greenberg, Gerald P. Smith, and James Gibbs; Am. J. Physiol. 259 (Regulatory Integrative Comp. Physiol. 28); R110-R118, (1990).
The Effects of Ileal Transposition and Jejunoileal Bypass on Food Intake and GI Hormone Levels in Rats; G.-L. Ferri, D. L. Sarson, J. M. Polak and S. R. Bloom; Physiology & Behavior, vol. 33, pp. 601-609 (1984).
An Integrated Organismic Response to Lower Gut Stimulation H.S. Koopmans; Scandinavian Journal of Gastroenterology Supplement No. 86, pp. 114-153 (1983).
Control of Body Weight by Lower Gut Signals; Henry S. Koopmans and Anthony Sclafani International Journal of Obesity, pp. 491-495 (1981).
Comparisons of the Effects on Satiety and Eating Behavior of Infusion of Lipid into the Different Regions of the Small Intestine; I McL Welch, C.P. Sepple, and N.W. Read; Gut, pp. 30
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