Composition and method for distinguishing virulent and non-virul

Details Composition and method for distinguishing virulent and non-virul Composition and method for distinguishing virulent and non-virul

1991-09-05

1995-07-04

Chambers, Jasemine C.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

4353201, 536 231, 935 76, 935 77, 935 78, C12Q 168

Patent

active

054299225

ABSTRACT:
Diagnostic assays based on the discovery of dimorphism in the p30 antigen and gene and the direct association of this dimorphism with the known bimodal virulence pattern. Assays can be based on different antigenic behavior of virulent (referred to here as type I) and avirulent (type II) p30 antigens or on the differences in the corresponding genes. There is a one-to-one relationship between the type I and type II antigen/genes and virulence. Specific genetic materials, specific antibodies, and analytical techniques that allow a diagnosis to be made between virulent and avirulent infections are disclosed.

REFERENCES:
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Gross et al., Infection and Immunology 59:4511-4516 (1991).
Bulow et al., J. Immunol. 147:3496-3500 (1991).
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Huynh et al., in "DNA Cloning" ed. Glover, vol. 1:94 (1985).
Johnson et al., Expt. parasit. 63:272-278 (1987).
Burg et al., J. Cell Biochem. 10A:145 (1986).
Burg et al., J. of Immunol. 144:3584-3591 (1988).

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