Chemistry: analytical and immunological testing – Hemoglobin – myoglobin – or occult blood
Patent
1989-06-06
1992-01-14
Hill, Jr., Robert J.
Chemistry: analytical and immunological testing
Hemoglobin, myoglobin, or occult blood
422 56, 422 57, 422 61, 435 28, 435805, 436169, G01N 2178, G01N 3372
Patent
active
050810405
ABSTRACT:
A diagnostic kit is disclosed for the detection of hemoglobin, myoglobin, ferritin, or the like substances having peroxidase-like activity in different mixtures of biological origin, such as fecal blood in toilet bowl, occult blood in the breath of internally bleeding horses, or myoglobin in the urine of severely muscle damaged victims. The kit includes, in an air, moisture, and light proof package, an inert water insoluble matrix, such as a sheet of paper, which has an area where a chemical composition containing a water soluble polymer, or polymers, is deposited in at least two separate steps of thin film coating, for the detection of the above substances. The composition further includes one or more oxygen donors, one or more organic peroxides or other suitable oxidizing agents, and a leuco-dye which gives a colored oxidation product when it is oxidized by the oxidizing agents with the hemoglobin or like substance acting as the catalyst. Also disclosed is a method of making the test device for use in the kit. Also disclosed is a method of making the test device for use in the kit.
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Patel Chandravadan
Sangha Jangbir S.
Helena Laboratories Corporation
Hill Jr. Robert J.
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