Chemistry: analytical and immunological testing – Peptide – protein or amino acid
Patent
1991-11-29
1994-07-05
Housel, James C.
Chemistry: analytical and immunological testing
Peptide, protein or amino acid
436 87, 436 88, 422 56, 2524081, G01N 3300
Patent
active
053267079
ABSTRACT:
A composition, test device and method of determining the presence or concentration of proteins, such as albumin, in a liquid test sample, such as urine. The test device includes a test pad with a carrier matrix incorporating a indicator reagent composition capable of interacting with proteins to produce a detectable response. The indicator reagent composition includes an indicator dye that is capable of interacting with albumin and undergoing a detectable color transition; a buffer; a hydrophobic polymeric compound having the general structural formula: ##STR1## wherein A is ##STR2## and PO is an oxypropylene unit, EO is an oxyethylene unit, y is a number in the range of 0 to about 20, z is a number in the range of 0 to about 20, the sum y+z is a number in the range of about 2 to about 20, and R.sub.2 and R.sub.3 are selected, independently, from the group consisting of hydrogen, an alkyl group, an aralkyl group, and an aryl group;
R.sub.1 is either methylene or oxygen;
n is a number in the range of one to about 8; and
E is hydrogen or methylol when R.sub.1 is methylene, or E is hydroxy when R.sub.1 is oxygen; and a suitable carrier which is water. The indicator reagent composition provides an improved color resolution in the test samples raving negative protein and trace amount of protein.
REFERENCES:
patent: 4013416 (1977-03-01), Rittersdorf et al.
patent: 5013527 (1991-05-01), Arai et al.
patent: 5049358 (1991-09-01), Lau
patent: 5096833 (1992-03-01), Lau et al.
patent: 5124266 (1992-06-01), Coryn et al.
patent: 5187104 (1993-02-01), Corey et al.
Franke Gunter
Salvati Michael
Sommer Ronald G.
Coe Roger N.
Housel James C.
Miles Inc.
Tran Lien
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