Composition adapted for the determination of tri-iodo thyronine

Details Composition adapted for the determination of tri-iodo thyronine Composition adapted for the determination of tri-iodo thyronine

1978-03-09

1981-02-10

Wiseman, Thomas G.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

435188, 424 12, C12Q 166, C12N 996

Patent

active

042502535

ABSTRACT:
A composition for diagnostic use is disclosed, more particularly for the dosage of tri-iodo thyronine in human blood serum: the subject composition comprises tri-iode thyronine as such and an enzyme which is covalently bonded to tri-iodo thyronine. A diagnostic method is also disclosed, which is intended for using the above specified composition in diagnostic runs. The method, briefly resumed, consists removing the tri-iodo thyronine of the serum sample being assayed by means of an insolubilized anti-T.sub.3 antibody and treating the residue with the sensibilized enzyme which is nothing else than the covalent formed by tri-iodo thyronine and an appropriate enzyme, such as carbonic anhydrase.

REFERENCES:
patent: 3817837 (1974-06-01), Rubenstein
patent: 3850752 (1974-11-01), Schuurs et al.
patent: 4040907 (1977-08-01), Ullman et al.
Wisdom, "Enzyme-Immunoassay," Clin. Chem., vol. 22, No. 8, (1976), pp. 1243-1255.
Barman, Enzyme Handbook, vol. II, Springer-Verlag New York, Inc., New York, (1969) pp. 762-763.

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