Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Reexamination Certificate
2006-12-05
2006-12-05
Salimi, Ali R. (Department: 1648)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
C435S007100
Reexamination Certificate
active
07144703
ABSTRACT:
Novel vaccine compositions are provided comprising a hepatitis B antigen formulated with aluminium phosphate. The vaccine compositions may additionally contain an inactivated hepatitis A virus, aluminium hydroxide and formol. The combined hepatitis A and B vaccine formulations can, if desired, be administered to human subjects in a 2 dose regimen. Suitable formulations are illustrated.
REFERENCES:
patent: WO 93/24148 (1993-12-01), None
patent: WO 96/26741 (1996-09-01), None
Ambrosch et al., “Clinical and Immunological Investigation of a New Combined Hepatitis A and Hepatitis B Vaccine”,Journal of Medical Virology, 44(4): 452-456 (1994).
Murphy et al., Fields Virology, Chapter 19, 2nd Edition, pp. 480-482 (1994).
Green et al., Israel Journal of Medical Sciences, vol. 30(5-6), pp. 485-488 (1994).
Frey, et al. “Interference of Antibody Production to Hepatitis B Surface Antigen in a Combination Hepatitis A/Hepatitis B Vaccine”The Journal of Infectious Diseases1999:180 pp. 2018-2022.
Artois Claude
Clark Michael J
Thiriart Clothilde
Thoelen Stefan Gabriel Jozef
Fedon Jason C.
Gimmi Edward R.
Kinzig Charles M.
Salimi Ali R.
SmithKline Beecham Biologicals (s.a.)
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