Composite salmonella E. coli, Vibrio cholerae vaccine strains

Details Composite salmonella E. coli, Vibrio cholerae vaccine strains Composite salmonella E. coli, Vibrio cholerae vaccine strains

1989-09-01

1992-05-05

Schwartz, Richard A.

Drug, bio-affecting and body treating compositions

Whole live micro-organism, cell, or virus containing

Genetically modified micro-organism, cell, or virus

4351722, 4351723, 4352523, 43525233, 935 65, A61K 39116, A61K 39106, A61K 39108, A61K 39112

Patent

active

051105888

ABSTRACT:
Composite bacterial strains useful as vaccines for the prophylactic treatment of enteric diseases are hybrids of Salmonella and E. coli in which E. coli-derived lipopolysaccharide cores expressed in a Salmonella organism serve as a scaffold upon which the O-antigen of yet another pathogenic bacterial species, such as Vibrio cholerae is constructed. Such strains, methods of their production, vaccine compositions comprising these strains, and methods of treating enteric disease with these vaccine compositions, are disclosed.

REFERENCES:
patent: 4588170 (1989-12-01), Curtis, III
patent: 4632830 (1986-12-01), Formal et al.
Rick, P. D., 1987 "Lipopolysaccharide Biosynthesis", In Escherichia coli and Salmonella Typhimurium, Ed. Neidhardt, F. C. American Society for Microbiology, Washington, DC pp. 648-662.
Raetz, C. R. V. 1987, "Structure and Biosynthesis of Lipid A in Escherichia coli" In Escherichia coli and Salmonella Typhimurium, Ed. Neidhardt, F. C. American Society for Microbiology, Washington DC, pp. 498-503.
Godard, C., et al. Biological Abstracts vol. 64, No. 9, p. 4917, Abstract 50115.
Guinee, P. A. M. et al. 1989, Biological Abstracts, vol. 87 No. 9, Abstract 93143.
Baron, L. S. et al. 1987, Infection and Immunity, vol. 55, No. 11, pp. 2797-2801.
Hohmann, A., et al. 1979, Infection and Immunity, vol. 25, No. 1, pp. 27-33.
Schmidt, et al.; Immunochemistry of R Lipopolysaccharides of E. coli; Eur. J. Biochem 16:382-392 (1970).

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