Composite pressure sensitive hydrophilic adhesive and method of

Details Composite pressure sensitive hydrophilic adhesive and method of Composite pressure sensitive hydrophilic adhesive and method of

1996-11-08

1998-09-15

Jagannathan, Vasu

Synthetic resins or natural rubbers -- part of the class 520 ser

Synthetic resins

At least one aryl ring which is part of a fused or bridged...

524379, 524386, 524513, 524524, 524526, 523111, 424DIG7, C08K 506, A61L 1500

Patent

active

058079173

DESCRIPTION:

BRIEF SUMMARY
TECHNICAL FIELD

The invention relates to a composite pressure sensitive adhesive particularly suitable for temporarily glueing medical and cosmetic means to the body surface from which it can be easily removed by liquid water or by innocuous diluted aqueous solutions.


BACKGROUND ART

There are known non-tacky hydrogel covers of burnt or wounded skin, consisting of a gelled mixture of water-insoluble, water swellable polymers such as poly(2-hydroxyethyl methacrylate), which can be either covalently crosslinked (three-dimensional) or solvent soluble noncrosslinked, with a polar high boiling solvent such as polyethylene glycol, preferably mixed with water either by sprinkling the liquid component onto skin and then powdering it with the ground dried polymer, or by mixing the two components just before the spreading. The mixture sets after a short time of up to about 50 minutes, forming a non-tacky layer which can be peeled off as such or after further wetting. (See U.S. Pat. Nos. 4,272,518 and 4,303,066). A combination of a crosslinked polymer with a polymer soluble in the above mentioned plasticizer is not disclosed. U.S. Pat. No. 4,460,562 discloses a polymeric diffusion matrix containing a drug (propanol) and consisting of from about 1% to about 60%, of polar highly boiling plasticizer such as glycerol, from about 2% to about 30% of poly(N-vinylpyrrolidone) and from about 6% to about 30% of at least 90% hydrolyzed poly(vinylacetate) together with a transdermally effective amount of propanol. These compositions, as discussed in the Examples, possess an inferior to the skin and insufficient elongation. Moreover, they display a tendency to the syneresis.
None of the above mentioned references relates to a pressure sensitive adhesive which could be utilized as such. All of them disclose mixtures of either crosslinked or non-crosslinked hydrophilic polymers--but no combination thereof--with polar high boiling point (plasticizers) and a minor amount of water, said mixtures setting on the skin so that they adhere to it. They cannot be used as adhesives for glueing medical means temporarily to the skin.
U.S. Pat. No. 4,595,053 describes hydrophilic pressure sensitive biomedical adhesives, comprising about from 27% to 50% of poly(N-vinylpyrrolidone), from about 2% to 5% of polyvinylalcohol, from 5% to about 40% of a polar plasticiser and about 5% to 50% of water. In this case all components are water-soluble and the mixture has to be heated in the presence of water to at least 95.degree. C. to form a melt capable to get gelled only upon cooling. The preparation requires a temperature-controlled stirrable reactor and temperatures up to 130.degree. C. No crosslinked or insoluble polymer is added. The mixture is set by cooling, not by heating.
Other pressure sensitive biomedical adhesives such as those described in the European Patent Specifications No EP 0092999 A2 and EP 0 130 061 A1 contain hydrophobic components such as synthetic rubber and mineral oil besides water-soluble gums, resins and tackifiers. They differ therefore distinctly from the present ones as defined below.


Disclosure of Invention

The object of the present invention is to provide a composite pressure sensitive hydrophilic adhesive, permeable for water vapor and which loses its adhesivness in contact with liquid water, that is particularly suitable for temporarily glueing medical means to the body surface, consisting of the gelled mixture of (a) a water swellable, water insoluble polymer, soluble in polar water-miscible solvents, boiling at atmospheric pressure at temperatures higher than 100.degree. C. as well as in their mixtures with minor amounts of water, a (b) hydrophilic water swellable polymer, insoluble in water as well as in polar water-miscible solvents boiling at atmospheric pressure at temperatures higher than 100.degree. C. and (c) a polar water-miscible innocuous solvent, boiling at atmospheric pressure at temperatures higher than 100.degree. C., and which, if desired, can be mixed with a minor amount of water.
Another object o

REFERENCES:
patent: 4303066 (1981-12-01), D'Andrea
patent: 5064652 (1991-11-01), Bay

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