Composite nanospheres and their conjugates with biomolecules

Details Composite nanospheres and their conjugates with biomolecules Composite nanospheres and their conjugates with biomolecules

2006-02-21

2006-02-21

Acquah, Samuel A. (Department: 1711)

Drug, bio-affecting and body treating compositions

In vivo diagnosis or in vivo testing

Ultrasound contrast agent

C424S009510, C424S489000, C424S490000, C424S497000, C428S402000, C428S402200, C428S402210, C428S402220

Reexamination Certificate

active

07001589

ABSTRACT:
The invention concerns composite nanospheres having a diameter ranging between about 50 and 1000 nm plus or minus 5%, preferably between about 100 and 500 nm plus or minus 5% and advantageously between 100 and 200 nm plus or minus 5%, and comprising an essentially liquid core consisting of an organic phase and inorganic nanoparticles, distributed inside the organic phase, and a skin consisting of at least a hydrophilic polymer derived from the polymerisation of at least one water soluble monomer, in particular N-alkylacrylamide or a N-N-dialkylacrylamide; conjugates derived from said nanospheres; their preparation methods and their uses.

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