Composite nanospheres and their conjugates with biomolecules

Details Composite nanospheres and their conjugates with biomolecules Composite nanospheres and their conjugates with biomolecules

2005-03-15

2005-03-15

Hartley, Michael G. (Department: 1616)

Drug, bio-affecting and body treating compositions

In vivo diagnosis or in vivo testing

Ultrasound contrast agent

C424S189100, C424S490000, C424S496000, C424S497000, C264S004000, C264S004100, C264S004300, C264S004320, C428S402000, C428S402200, C428S402220

Reexamination Certificate

active

06866838

ABSTRACT:
The invention concerns composite nanospheres having a diameter ranging between about 50 and 1000 nm plus or minus 5%, preferably between about 100 and 500 nm plus or minus 5% and advantageously between 100 and 200 nm plus or minus 5%, and comprising an essentially liquid core consisting of an organic phase and inorganic nanoparticles, distributed inside the organic phase, and a skin consisting of at least a hydrophilic polymer derived from the polymerisation of at least one water soluble monomer, in particular N-alkylacrylamide or a N—N-dialkylacrylamide; conjugates derived from said nanospheres; their preparation methods and their uses.

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