Composite for biased solid phase radioimmunoassay of triiodothyr

Details Composite for biased solid phase radioimmunoassay of triiodothyr Composite for biased solid phase radioimmunoassay of triiodothyr

1975-03-28

1977-07-05

Padgett, Benjamin R.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

Molecular bilayer structure

23230B, 232306, 424 12, G01N 3300, G01N 3316

Patent

active

040340732

ABSTRACT:
Immunochemical composites consisting of saturating amounts of radio-labelled triiodothyronine (T.sub.3) or thyroxine (T.sub.4) complexed respectively to anti-T.sub.3 or anti-T.sub.4 antisera covalently coupled to suspendable porous glass particles via an intermediate silane coupling agent. The composites are pre-loaded into individual tubes used in solid phase radioimmunoassay of T.sub.3 or T.sub.4, requiring the addition of only test serum or standard, thereby minimizing chances of erroneous assay.

REFERENCES:
patent: 3519538 (1970-07-01), Messing et al.
patent: 3646346 (1972-02-01), Catt
patent: 3652761 (1972-03-01), Weetall
patent: 3799740 (1974-03-01), Mincey
patent: 3904373 (1975-09-01), Harper
Weetall, Biochem. Journal, vol. 117, 1970, pp. 257-261.
Weetall, Biochimica et Biophysica Acta, vol. 212, No. 1, July 15, 1970, pp. 1-7.

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