Chemistry: molecular biology and microbiology – Treatment of micro-organisms or enzymes with electrical or... – Modification of viruses
Patent
1995-06-07
1999-11-02
Cunningham, Thomas M.
Chemistry: molecular biology and microbiology
Treatment of micro-organisms or enzymes with electrical or...
Modification of viruses
435328, 435344, 5303873, 5303877, 5303888, 4241331, 4241381, C12N 1507, C07K 1630
Patent
active
059768452
ABSTRACT:
This invention concerns a subset of composite Hum4 V.sub.L, V.sub.H antibodies with high affinities to a high molecular weight, tumor-associated sialylated glycoprotein antigen (TAG-72) of human origin. These antibodies have variable regions with (1) V.sub.L segments derived from the human subgroup IV germline gene, and (2) a V.sub.H segment which is capable of combining with the V.sub.L to form a three dimensional structure having the ability to bind TAG-72. In vivo methods of treatment and diagnostic assay using these composite antibodies is also disclosed.
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Johnson Kimberly S.
Mezes Peter S.
Richard Ruth A.
Cunningham Thomas M.
Kimble Karen L.
Scott Mark S.
The Dow Chemical Company
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