Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Structurally-modified antibody – immunoglobulin – or fragment...
Patent
1994-06-16
1999-11-02
Cunningham, Thomas M.
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
Structurally-modified antibody, immunoglobulin, or fragment...
4241551, 435 792, 5303873, 5303888, 53038885, 5303913, 5303917, A61K 39395, C07H 1630
Patent
active
059765313
ABSTRACT:
This invention concerns a subset of composite Hum4 V.sub.L, V.sub.H antibodies with high affinities to a high molecular weight, tumor-associated sialylated glycoprotein antigen (TAG-72) of human origin. These antibodies have variable regions with (1) V.sub.L segments derived from the human subgroup IV germline gene, and (2) a V.sub.H segment which is capable of combining with the V.sub.L to form a three dimensional structure having the ability to bind TAG-72. In vivo methods of treatment and diagnostic assay using these composite antibodies is also disclosed.
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Johnson Kimberly S.
Mezes Peter S.
Richard Ruth A.
Cunningham Thomas M.
Kimble Karen L.
Scott Mark S.
The Dow Chemical Company
Ulmer Duane
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