Composite anesthetic article and method of use

Details Composite anesthetic article and method of use Composite anesthetic article and method of use

1989-03-06

1993-05-11

Rosenbaum, C. Fred

Surgery

Means for introducing or removing material from body for...

Material introduced into and removed from body through...

424686, A61M 3100

Patent

active

052097242

ABSTRACT:
An aqueous composition for reducing pain at the site of injection of local parenteral anesthetic material, for improving the onset thereof, and for increasing its duration, and a means for preparing and dispensing the same, the composition containing a local parenteral anesthetic which in normal doses gives an acid pH of from about 5 to about 6.9, wherein the anesthetic comprises from about 0.5 to about 2.0% weight of the composition, the composition further containing sufficient NaHCO.sub.3 to maintain the pH thereof between about 7.0 and about 7.6, and further containing from about 0.0004 moles of dissolved CO.sub.2 per ml of composition up to the saturation level of dissolved CO.sub.2 at a CO.sub.2 head pressure of up to about 2.5 atmospheres.

REFERENCES:
patent: 3978212 (1976-08-01), Barna
patent: 4663166 (1987-05-01), Veech
patent: 4861592 (1989-08-01), Gottwald
Condouris et al., "Potentiation of the Nerve-Depressant Effect of Local Anesthetics by CO.sub.2 " Nature, Oct. 3, 1964, pp. 57-59.
Martin et al., "Effects of Carbon Dioxide . . . " Canad. Anaesth. Soc., vol. 28, No. 3, May 1981 pp. 224-227.
McKay et al., "Sodium Bicarbonate Attenuates Pain . . . ", Anesth Analg, vol. 66, 1987, pp. 572-574.

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