Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues
Reexamination Certificate
2005-02-22
2005-02-22
Nickol, Gary B. (Department: 1642)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
C530S835000, C530S828000
Reexamination Certificate
active
06858709
ABSTRACT:
Rbx1, an evolutionarily conserved Cullin-interacting RING-H2 finger protein, has been discovered. Mammalian Rbx1 has been identified as a component of the CUL2-containing VHL complex. An Rbx1 homolog fromS. cerevisiaehas also been identified as a subunit and activator of the Cdc53-containing SCFCdc4ubiquitin ligase required for ubiquitination of the cdk inhibitor Sic1 and for the G1/S cell cycle transition in yeast, providing a link between the multiprotein VHL tumor suppressor complex and cellular ubiquitination. The Rbx1 protein acts as a cellular marker useful (1) in detecting a possible predisposition to certain carcinomas, (2) as a molecular target for treating those carcinomas therapeutically. (3) as a target for inhibition by drugs that manipulate the growth of cells, and (4) as a research tool to better understand the various complex mechanisms of cell ubiquitination, binding of certain activator proteins, fibronectin deposition and other aspects of the cellular division process.
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Pause et al. (Proc.Natl.Acad.Sci., Mar. 1997, vol. 94, pp. 2156-2161).*
Ohta, et al., “ROC1, A Homolog of APC11, Represents a Family of Cullin Partners with an Associated Ubiquitin Ligase Activity”, Mol. Cell, vol. 3, pp. 535-541, (Apr. 1999).
Alliel, et al., “Testican, A Multidomain Testicular Proteoglycan Resembling Modulators of Cell Social Behavior”, Eur. J. Biochem. pp. 214, 347-350 (1993).
Kamura, et al., “RBX1, A Component of the VHL Tumor Suppressor Complex and SCF Ubiquitin Ligase”, Science, vol. 284, pp. 657-681, (Apr. 23, 1999).
Conaway Joan W.
Conaway Ronald C.
Kamura Takumi
Oklahoma Medical Research Foundation
Townsend and Townsend / and Crew LLP
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