Compliant tissue sealants

Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Implant or insert

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424489, 424490, 528354, 528361, 128898, 525 541, 525 542, 525408, 525413, 525415, 5147721, 5147723, 514773, 514777, C09D 400, A61L 2500, A61L 2700, A61L 2900

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active

059002450

ABSTRACT:
An improved barrier or drug delivery system which is highly adherent to the surface to which it is applied is disclosed, along with methods for making the barrier. In the preferred embodiment, the system is compliant, in that it is capable of conforming to the three dimensional structure of a tissue surface as the tissue bends and deforms during healing processes. The barrier or drug delivery systems is formed as a polymeric coating on tissue surfaces by applied a polymerizable monomer to the surface, and then polymerizing the monomer. The polymerized compliant coating preferably is biodegradable and biocompatible, and can be designed with selected properties of compliancy and elasticity for different surgical and therapeutic applications.

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