Surgery – Diagnostic testing – Cardiovascular
Reexamination Certificate
2006-02-17
2009-10-13
Evanisko, George R (Department: 3762)
Surgery
Diagnostic testing
Cardiovascular
C600S515000
Reexamination Certificate
active
07601124
ABSTRACT:
In a subject undergoing therapeutic intervention, efficacy of the therapeutic intervention is assessed based on a series of physiologic data associated with the subject. The series of physiologic data is analyzed to produce a measure of complexity. The complexity measure is then compared to a control. The efficacy of the therapeutic intervention is assessed based on the comparison of the complexity measure to the control. The control may be, for example, a complexity measure taken prior to initiation of the therapeutic intervention, a complexity measure taken from a different subject, or a predetermined threshold value. The measure of complexity is generated using, for example, a multiscale entropy measurement (MSE), a time asymmetry measurement, and/or an information-based similarity measurement. An increase in complexity indicates a positive effect of the therapeutic intervention, while a decrease in complexity indicates a negative effect of the therapeutic intervention.
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Costa Madalena D.
Goldberger Ary L.
Peng Chung-Kang
Beth Israel Deaconess Medical Center
Dietrich Joseph M
Evanisko George R
Sterne Kessler Goldstein & Fox P.L.L.C.
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