Organic compounds -- part of the class 532-570 series – Organic compounds – Radioactive metal containing
Patent
1993-05-03
1994-09-27
Stoll, Robert L.
Organic compounds -- part of the class 532-570 series
Organic compounds
Radioactive metal containing
5303915, C07F 1300
Patent
active
053508378
ABSTRACT:
The ligand L, (R.sup.3)(R.sup.4)(R.sup.5)C--N(R)--C(R.sup.1)(R.sup.2)--(CH.sub.2).sub.n --COOH L where R is hydrogen, hydroxy, alkyl, hydroxyalkyl, or alkylcarboxy, or R and R.sup.1 together may form a mono-, di-, tri-, or tetra-methylene radical, or R and R.sup.3 together may form a mono-, di-, tri-, or tetra-methylene radical, and R.sup.1 and R.sub.2 may be the same or different and are selected from hydrogen, hydroxy, alkyl, hydroxyalkyl, carboxy, alkylcarboxy, alkylamine, alkylthiol, aryl or R.sup.1 and R.sup.2 together may form a tetra- or penta-methylene radical, and R.sup.3 and R.sup.4 and R.sup.5 may be the same or different and are selected from hydrogen, hydroxy, alkyl, hydroxyalkyl, carboxy, alkylcarboxy, provided that at least one of R.sup.3, R.sup.4 and R.sup.5 is hydroxyalkyl, and n is equal to 0, 1 or 2, for example tricine, form useful complexes with .sup.99m Tc, for radiolabelling macromolecules such as monoclonal antibodies.
REFERENCES:
patent: 4017596 (1977-04-01), Loberg et al.
patent: 4113850 (1978-09-01), Benes
patent: 4425280 (1984-01-01), Ito
patent: 4772724 (1988-09-01), Wright et al.
patent: 5198208 (1993-03-01), Berg et al.
Mighri et al., Bulletin De La Societe Chimique De France, No. 5-6, 1975, pp. 1160-1654.
Chemical Abstracts, vol. 79, 1973, Abstract No. 66815g, Frezou et al., p. 485, J. Chim. Phys. Physicochim. Biol., vol. 70, No. 5, 1973, pp. 861-863.
Chemical Abstracts, vol. 89, 1978, Abstract No. 80938n, Kapoor et al., p. 360, J. Inorg. Nucl. Chem., vol. 40, No. 1, 1978, pp. 155-158.
Chemical Abstracts, vol. 95, 1981, Abstract No. 9305u, Kalincak et al., p. 253, Int. J. Appl. Radiat. Isot., vol. 32, No. 7, 1981, pp. 493-499.
Kishan, et al., "Complex Formation of Indium(III) with N-[tris(hydroxy-methyl)methyl]glycine and N,N-(dihydroxymethyl)glycine", Trans. Saest 15(4), 327-31, 1980; published in Chem. Abs. as CA95(2): 13633r, Jul. 6, 1981.
Bridger Gary J.
Hernandez Pedro E.
Higgins, III John D.
Larsen Scott K.
Chapman Lara E.
Johnson Matthey Public Limited Company
Stoll Robert L.
LandOfFree
Complexes with .sup.99m Tc suitable for radiolabelling monoclona does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Complexes with .sup.99m Tc suitable for radiolabelling monoclona, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Complexes with .sup.99m Tc suitable for radiolabelling monoclona will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1266541