Drug – bio-affecting and body treating compositions – Radionuclide or intended radionuclide containing; adjuvant... – In an organic compound
Patent
1992-06-17
1994-08-30
Stoll, Robert L.
Drug, bio-affecting and body treating compositions
Radionuclide or intended radionuclide containing; adjuvant...
In an organic compound
534 10, A61K 4300, A61K 4902, C07F 300, C07F 500
Patent
active
053426045
ABSTRACT:
A group of functionalized amine chelants having ortho ligating functionality that form complexes with rare-earth type metal ions are disclosed. The chelants possess the general formula ##STR1## wherein R.sup.'1, R.sup.'2, R.sup.'3, R.sup.'4, R.sup.'5 and R.sup.'6, Z' and X are all defined in the specification. In addition certain of the chelant-radionuclide complexes can be effectively employed in compositions useful as therapeutic and/or diagnostic agents for calcific tumors and/or relief of bone pain.
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Frank R. Keith
Garlich Joseph R.
McMillan Kenneth
Simon Jaime
Wilson David A.
Covert John M.
Kimble Karen L.
Stoll Robert L.
The Dow Chemical Company
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