Complexes of technetium-99m with propylene amine oximes

Details Complexes of technetium-99m with propylene amine oximes Complexes of technetium-99m with propylene amine oximes

1986-03-11

1988-12-06

Terapane, John F.

Organic compounds -- part of the class 532-570 series

Organic compounds

Radioactive metal containing

424 11, 564253, 564268, C07C13114, C07C13108, C07F 1700, A61K 4902

Patent

active

047897368

ABSTRACT:
A family of propylene amine oxime ligands has the formula 2 ##STR1## wherein preferably R.sup.1 is Cl-C4 alkyl or phenyl and each of R, R.sup.2, R.sup.3 and R.sup.4 is H or Cl-C4 alkyl. The technetium-99m complexes of these ligands are lipophilic neutral complexes useful as diagnostic radiopharmaceuticals and particularly for brain scanning. The ligands show stereoisomerism. The preparation and properties of the dl- and meso-stereoisomers, and of the d- and l-enantiomers, are described. The l-enantiomer and the dl-stereoisomer of the preferred compound (2, R=R.sup.1 =R.sup.2 =CH.sub.3, R.sup.3 =R.sup.4 =H) show good retention in the brain.

REFERENCES:
patent: 4615876 (1986-10-01), Troutner et al.
Smith, D. F., CRC Handbook of Stereoisomers: Drugs in Psychopharmacology, ed. D. F. Smith, CRC, Boca Raton, Fla. 1984, p. 11.

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